Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington.
Department of Laboratory Medicine, University of Washington, Seattle, Washington.
J Clin Endocrinol Metab. 2020 Dec 1;105(12):e4337-50. doi: 10.1210/clinem/dgaa612.
A comprehensive characterization of racial/ethnic variations in vitamin D metabolism markers may improve our understanding of differences in bone and mineral homeostasis and the risk of vitamin D-related diseases.
Describe racial/ethnic differences in vitamin D metabolism markers and their associations with genetic ancestry.
DESIGN, SETTING, PARTICIPANTS: In a cross-sectional study within the Multi-Ethnic Study of Atherosclerosis (MESA), we compared a comprehensive panel of vitamin D metabolism markers across self-reported racial/ethnic groups of Black (N = 1759), White (N = 2507), Chinese (N = 788), and Hispanic (N = 1411). We evaluated associations of proportion African and European ancestry with this panel of markers in Black and Hispanic participants using ancestry informative markers. Latent class analysis evaluated associations between patterns of vitamin D measurements with race/ethnicity.
Compared with Black participants, White participants had significantly higher serum concentrations of 25-hydroxyvitamin D and fibroblast growth factor-23; lower concentrations of parathyroid hormone and 1,25-dihydroxyvitamin D; circulating vitamin D metabolite ratios suggesting lower CYP27B1 and higher CYP24A1 activity; higher urinary concentrations of calcium and phosphorus with higher urinary fractional excretion of phosphorus; and differences in vitamin D binding globulin haplotypes. Higher percent European ancestry was associated with higher 25-hydroxyvitamin D and lower parathyroid hormone concentrations among Black and Hispanic participants. Latent classes defined by vitamin D measurements reflected these patterns and differed significantly by race/ethnicity and ancestry.
Markers of vitamin D metabolism vary significantly by race/ethnicity, may serve to maintain bone and mineral homeostasis across ranges of 25-hydroxyvitamin D production, and be attributable, at least partly, to genetic ancestry.
全面描述维生素 D 代谢标志物的种族/民族差异，可能有助于我们理解骨骼和矿物质动态平衡的差异，以及与维生素 D 相关疾病的风险。
描述维生素 D 代谢标志物的种族/民族差异及其与遗传背景的关系。
设计、地点、参与者：在动脉粥样硬化多民族研究（MESA）的一项横断面研究中，我们比较了自我报告的黑种人（N=1759）、白种人（N=2507）、中国人（N=788）和西班牙裔（N=1411）组的维生素 D 代谢标志物的综合指标。我们使用遗传信息标记物评估了黑人和西班牙裔参与者中非洲和欧洲血统比例与该标志物组的关联。潜在类别分析评估了维生素 D 测量模式与种族/民族之间的关联。
与黑人参与者相比，白人参与者的血清 25-羟维生素 D 和成纤维细胞生长因子 23 浓度明显较高；甲状旁腺激素和 1,25-二羟维生素 D 浓度较低；循环维生素 D 代谢物比值提示 CYP27B1 活性降低，CYP24A1 活性升高；钙和磷的尿浓度较高，磷的尿分数排泄较高；维生素 D 结合球蛋白单倍型也存在差异。黑人及西班牙裔参与者的欧洲血统比例越高，25-羟维生素 D 浓度越高，甲状旁腺激素浓度越低。根据维生素 D 测量值定义的潜在类别反映了这些模式，且与种族/民族和遗传背景显著不同。
维生素 D 代谢标志物在种族/民族之间存在显著差异，可能有助于在 25-羟维生素 D 生成范围内维持骨骼和矿物质动态平衡，至少部分归因于遗传背景。
