坏死性小肠结肠炎的围产期危险因素。
Perinatal risk factors for necrotizing enterocolitis.
作者信息
Yu V Y, Joseph R, Bajuk B, Orgill A, Astbury J
出版信息
Arch Dis Child. 1984 May;59(5):430-4. doi: 10.1136/adc.59.5.430.
The perinatal histories of 50 very low birthweight infants weighing 1500 g, or less, with necrotizing enterocolitis were compared with those of the remaining 325 very low birthweight infants who were admitted to this hospital during a four year study period. Many factors previously reported to be associated with necrotizing enterocolitis were found with equal frequency in both groups of babies. The only adverse factor which was more frequently present in patients with necrotizing enterocolitis was hypothermia on admission to hospital. Those infants who developed severe necrotizing enterocolitis also had a higher incidence of polycythaemia. A further controlled study which examined feeding practices showed that the timing, type, and volume of milk feeding were not different in infants with necrotizing enterocolitis and matched controls. Prematurity is clearly the greatest risk factor which predisposes to the development of necrotizing enterocolitis and most of the factors previously implicated in the aetiology may simply represent the descriptive characteristics of a population of sick, very low birthweight infants.
对50名出生体重1500克及以下且患有坏死性小肠结肠炎的极低出生体重儿的围产期病史，与在四年研究期间入住本院的其余325名极低出生体重儿的围产期病史进行了比较。先前报道的许多与坏死性小肠结肠炎相关的因素在两组婴儿中出现的频率相同。坏死性小肠结肠炎患者中更常出现的唯一不利因素是入院时体温过低。那些发生严重坏死性小肠结肠炎的婴儿红细胞增多症的发生率也更高。另一项关于喂养方式的对照研究表明，坏死性小肠结肠炎婴儿与匹配的对照组在喂奶时间、类型和量方面并无差异。早产显然是导致坏死性小肠结肠炎发生的最大风险因素，先前病因学中涉及的大多数因素可能仅仅代表了患病的极低出生体重儿群体的描述性特征。
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