Lademann Hanne, Darvin Maxim E, Häfke Anna, Lademann Jürgen, Wagner Laura, Däbritz Jan, Olbertz Dirk M
Department of Pediatrics, Rostock University Medical Center, 18057 Rostock, Germany.
Independent Researcher, 10178 Berlin, Germany.
Life (Basel). 2025 Mar 24;15(4):534. doi: 10.3390/life15040534.
Postpartum adaptation causes an increased formation of free radicals (FRs) in the organism, which can lead to development of various FR-mediated diseases (FRMDs) in the newborn. The present study investigates the kinetics of skin and blood carotenoid antioxidants in term and preterm infants and the influence of FRMD. In the first phase, a diffuse reflectance spectroscopy-based scanner was validated for non-invasive measurements of skin carotenoids in term infants (thenar eminence) by correlation with blood carotenoids via reflection spectroscopy. In the second phase, the skin and blood carotenoids of 22 term and 13 preterm infants with and without FRMD were assessed from birth until discharge. It could be shown that the scanner reliably assessed carotenoids in the infants' skin. The term and preterm infants showed similar kinetics of skin carotenoids, which increased and entered a plateau after 3-4 days. In our cohort, FRMD did not have a significant influence on skin carotenoid concentration. This was due to immature sweat glands and an insufficient excretion of carotenoids. Skin carotenoids seem to be unavailable, suggesting that they may have to be supplemented in infants with FRMD. Blood carotenoid concentrations tended to be lower in preterm infants and infants with FRMD compared to healthy term infants.
产后适应会导致机体中自由基（FRs）生成增加，这可能会致使新生儿患上各种由自由基介导的疾病（FRMDs）。本研究调查了足月儿和早产儿皮肤及血液中类胡萝卜素抗氧化剂的动力学以及FRMD的影响。在第一阶段，通过反射光谱法将基于漫反射光谱的扫描仪与血液类胡萝卜素进行相关性分析，从而验证其用于非侵入性测量足月儿（鱼际隆起处）皮肤类胡萝卜素的有效性。在第二阶段，对22名足月儿和13名早产儿在出生至出院期间有无FRMD的皮肤和血液类胡萝卜素进行了评估。结果表明，该扫描仪能够可靠地评估婴儿皮肤中的类胡萝卜素。足月儿和早产儿的皮肤类胡萝卜素动力学相似，在3 - 4天后升高并进入平台期。在我们的队列中，FRMD对皮肤类胡萝卜素浓度没有显著影响。这是由于汗腺未成熟以及类胡萝卜素排泄不足。皮肤类胡萝卜素似乎无法利用，这表明可能需要对患有FRMD的婴儿进行补充。与健康足月儿相比，早产儿和患有FRMD的婴儿血液类胡萝卜素浓度往往较低。
