Leeuwin R S, Belling G A, Rödiger G T, Njio K D, van Wilgenburg H
Department of Pharmacology, University of Amsterdam, The Netherlands.
Eur J Pharmacol. 1987 Jul 2;139(1):129-32. doi: 10.1016/0014-2999(87)90508-5.
The effect of diazepam (Valium), administered by i.p. injection on the cross-sectional area of synaptic vesicle profiles of the endplate-rich area of the rate diaphragm was studied by electron microscopy at 15-180 min after treatment. In the dose range of 0.25-10 mg/kg, diazepam induced a significant increase of the size of the synaptic vesicles. This increase was dose-related within a certain margin, dependent on the treatment time, while the effect of each dose increased significantly with the period after treatment. At 2.5-10 mg/kg a maximum seemed to be reached at 90 min.
通过电子显微镜研究了腹腔注射地西泮（安定）对大鼠膈肌富含终板区域突触小泡轮廓横截面积的影响，观察时间为给药后15 - 180分钟。在地西泮剂量为0.25 - 10mg/kg范围内，可使突触小泡大小显著增加。在一定范围内这种增加与剂量相关，并取决于治疗时间，且每个剂量的效应随给药后的时间显著增加。在2.5 - 10mg/kg剂量时，似乎在90分钟达到最大值。
