Wen Zhi-Fei, Peng Si-Han, Wang Jia-Lin, Wang Hong-Yan, Yang Li-Ping, Liu Qin, Zhang Xian-Geng
School of Nursing, Chengdu university of Traditional Chinese Medicine, Sichuan, China.
School Clinical, Chengdu university of Traditional Chinese Medicine, Sichuan, China.
Aging Ment Health. 2023 Jul-Aug;27(8):1443-1455. doi: 10.1080/13607863.2022.2158305. Epub 2022 Dec 19.
Motoric cognitive risk syndrome (MCR) is a newly proposed pre-dementia syndrome. Several studies on the prevalence of MCR have been published; however, the data vary across studies with different epidemiological characteristics. Thus, this study aimed to quantitatively analyse the overall prevalence and associated epidemiological characteristics of MCR among older adults aged ≥ 60 years.
The Cochrane Library, PubMed, Web of Science, CINAHL, Embase, Scopus, PsycInfo, China National Knowledge Infrastructure, Weipu Database, China Biology Medicine disc and Wanfang Database were searched from their inception to January 2022. A modified Newcastle-Ottawa Scale evaluated the risk of bias. Statistical heterogeneity among the included studies was analysed using Cochran's Q and I tests. A random effect model calculated pooled prevalence owing to study heterogeneity. Begg's and Egger's tests were used to assess the publication bias. Additionally, subgroup analysis and meta-regression were performed based on different epidemiological characteristics to determine heterogeneity sources.
Sixty-two studies comprising 187,558 samples were obtained. The pooled MCR prevalence was 9.0% (95% confidence interval: 8.3-9.8). A higher MCR prevalence was observed in females, older adults with a low educational level, depression and cardiovascular risk factors, South American populations, and studies with small sample sizes and cross-section designs. Furthermore, subjective cognitive complaint using scale score and gait speed using instrument gait showed higher MCR prevalence.
MCR is common in older adults, and various epidemiological characteristics influence its prevalence. Thus, preventive measures are required for older adults with higher MCR prevalence.
运动认知风险综合征（MCR）是一种新提出的痴呆前综合征。已有多项关于MCR患病率的研究发表；然而，不同流行病学特征的研究数据存在差异。因此，本研究旨在定量分析60岁及以上老年人中MCR的总体患病率及相关流行病学特征。
检索Cochrane图书馆、PubMed、科学网、CINAHL、Embase、Scopus、PsycInfo、中国知网、维普数据库、中国生物医学光盘数据库和万方数据库，检索时间从建库至2022年1月。采用改良的纽卡斯尔-渥太华量表评估偏倚风险。使用Cochran's Q检验和I²检验分析纳入研究之间的统计异质性。由于研究存在异质性，采用随机效应模型计算合并患病率。使用Begg检验和Egger检验评估发表偏倚。此外，基于不同的流行病学特征进行亚组分析和meta回归，以确定异质性来源。
共纳入62项研究，样本量为187558例。MCR合并患病率为9.0%（95%置信区间：8.3-9.8）。女性、低教育水平的老年人、患有抑郁症和心血管危险因素的人群、南美人群以及样本量小和采用横断面设计的研究中，MCR患病率较高。此外，使用量表评分的主观认知主诉和使用仪器测量的步态速度显示MCR患病率较高。
MCR在老年人中很常见，多种流行病学特征影响其患病率。因此，对于MCR患病率较高的老年人需要采取预防措施。
