Department of Biology, faculty of Science, University Ibn Tofail, kenitra , Morocco.
department of Biology, faculty of Science, University Ibn Tofail, kenitra , Morocco .
Acta Biomed. 2022 Dec 16;93(6):e2022322. doi: 10.23750/abm.v93i6.13673.
Celiac disease is an autoimmune enteropathy of the small intestine, related to gluten intolerance occurring in genetically predisposed patients. Currently, the only available treatment is a lifelong gluten-free diet. However, the total avoidance of gluten is difficult and poses a challenge to patients, nutritionists and treating physicians. For this reason, scientists have developed in recent years new therapeutic approaches complementary to dietary treatment, such as modification of gluten to make gliadin non-toxic, reduction of the inflammatory response with elafin and Lactococcus Lactis, degradation of gluten by endoproteolytic enzymes, and correction of nutritional deficiencies by adding pseudo-cereals to the diet of celiac patients. This literature review focuses on the different treatment strategies for celiac disease previously studied and summarizes the latest advances in this field.
乳糜泻是一种与麸质不耐受相关的小肠自身免疫性疾病，发生于遗传易感患者。目前，唯一可用的治疗方法是终生无麸质饮食。然而，完全避免麸质对患者、营养师和治疗医生来说都极具挑战。出于这个原因，近年来科学家们开发了一些新的治疗方法来补充饮食治疗，如修饰使麦胶蛋白无毒的麸质、用 Elafin 和 Lactococcus Lactis 减少炎症反应、用内肽酶降解麸质，以及通过向乳糜泻患者的饮食中添加假谷物来纠正营养缺乏。本文的文献综述重点介绍了之前研究过的乳糜泻的不同治疗策略，并总结了该领域的最新进展。
