Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain.
Nutrients. 2021 Jun 23;13(7):2146. doi: 10.3390/nu13072146.
To date, the only treatment for celiac disease (CD) consists of a strict lifelong gluten-free diet (GFD), which has numerous limitations in patients with CD. For this reason, dietary transgressions are frequent, implying intestinal damage and possible long-term complications. There is an unquestionable need for non-dietary alternatives to avoid damage by involuntary contamination or voluntary dietary transgressions. In recent years, different therapies and treatments for CD have been developed and studied based on the degradation of gluten in the intestinal lumen, regulation of the immune response, modulation of intestinal permeability, and induction of immunological tolerance. In this review, therapeutic lines for CD are evaluated with special emphasis on phase III and II clinical trials, some of which have promising results.
迄今为止，治疗乳糜泻 (CD) 的唯一方法是严格的终生无麸质饮食 (GFD)，但这对 CD 患者有诸多限制。出于这个原因，饮食违规行为很常见，这意味着肠道损伤和可能的长期并发症。因此，确实需要非饮食替代方案来避免因非故意污染或自愿饮食违规而造成的损伤。近年来，基于在肠腔中降解麸质、调节免疫反应、调节肠道通透性和诱导免疫耐受，已经开发和研究了不同的乳糜泻治疗方法和治疗药物。在这篇综述中，我们评估了治疗 CD 的各种方法，特别强调了 III 期和 II 期临床试验，其中一些具有很有前途的结果。
