三氯乙酸联合微针治疗与单纯三氯乙酸治疗黄褐斑的对比研究
Trichloroacetic Acid With Microneedling Versus Trichloroacetic Acid Alone for Treating Melasma.
作者信息
Hofny Eman R, Abdel-Motaleb Amira A, Hamed Safaa Ahmed, Twisy Howida Omar
机构信息
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University Hospitals, Egypt.
Draw Central Hospital, Aswan, Egypt.
出版信息
Dermatol Surg. 2023 Jan 1;49(1):66-71. doi: 10.1097/DSS.0000000000003641. Epub 2022 Dec 6.
BACKGROUND
Melasma is a common acquired disorder of hyperpigmentation which is difficult to treat.
OBJECTIVE
We aim to evaluate the efficacy and safety of combined microneedling with trichloroacetic acid in the treatment of melasma.
PATIENTS AND METHODS
Forty women with facial melasma were included and randomly classified into 2 groups. Group A included 20 patients treated with bimonthly session of trichloroacetic acid 25% peeling (8 sessions) combined with a monthly session of microneedling (4 sessions). Group B included the other 20 patients that were treated by bimonthly trichloroacetic acid 25% peeling session (8 sessions) alone.
RESULTS
After 1 and 3 months of treatment, the mean melasma area and severity index, modified melasma area and severity index, and melasma severity index scores showed significant improvement in each group (p < .05 for each). At 1 and 3 months, the mean percentages of change of all scores were significantly higher in group A than group B (p < .05).
CONCLUSION
Combined trichloroacetic acid peel with microneedling is effective and a safe option for treating melasma.
背景
黄褐斑是一种常见的获得性色素沉着紊乱疾病，难以治疗。
目的
我们旨在评估微针联合三氯乙酸治疗黄褐斑的疗效和安全性。
患者和方法
纳入40名面部黄褐斑女性患者，并随机分为2组。A组包括20名患者，接受每两个月一次的25%三氯乙酸剥脱治疗（共8次），并每月进行一次微针治疗（共4次）。B组包括另外20名患者，仅接受每两个月一次的25%三氯乙酸剥脱治疗（共8次）。
结果
治疗1个月和3个月后，每组的平均黄褐斑面积和严重程度指数、改良黄褐斑面积和严重程度指数以及黄褐斑严重程度指数评分均有显著改善（每组p < 0.05）。在1个月和3个月时，A组所有评分的平均变化百分比均显著高于B组（p < 0.05）。
结论
三氯乙酸剥脱联合微针治疗黄褐斑是一种有效且安全的选择。
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