*All authors are affiliated with the Department of Dermatology and Venereology, Government Medical College and Hospital, Chandigarh, India.
All authors are affiliated with the Department of Dermatology and Venereology, Government Medical College and Hospital, Chandigarh, India.
Dermatol Surg. 2019 Nov;45(11):1394-1400. doi: 10.1097/DSS.0000000000001964.
To study and compare the therapeutic efficacy and side effects of a 35% glycolic acid (GA) full face peel alone or in combination with a 10% or 20% trichloroacetic acid (TCA) spot peel for facial melasma.
Thirty patients with facial melasma were randomly divided into 3 equal Groups A, B, and C. Group A was treated with a 35% GA full-face peel, Group B and C with 35% GA full-face peel followed by a 10% and 20% TCA spot peel respectively once every 15 days. Four peels were performed once every 15 days. The response to the treatment was evaluated by the percentage reduction in melasma area severity index (MASI) scoring.
All 3 groups had significant reduction of MASI, but there was no significant difference between the groups. Group A had minimum side effects.
Chemical peels with GA alone or in combination with TCA do result in a significant improvement in melasma, but the combination of the peels in the same sitting does not seem to have any additive or synergistic effect while they may increase the side effects.
研究并比较单独使用 35%甘醇酸（GA）全脸换肤或联合使用 10%或 20%三氯乙酸（TCA）点蚀换肤治疗面部黄褐斑的疗效和副作用。
30 名面部黄褐斑患者随机分为 3 组，每组 10 名。A 组接受 35%GA 全脸换肤，B 组和 C 组接受 35%GA 全脸换肤后，每隔 15 天分别接受 10%和 20%TCA 点蚀换肤一次。每 15 天进行一次，共进行 4 次。通过黄褐斑面积严重程度指数（MASI）评分的减少百分比评估治疗反应。
所有 3 组的 MASI 均显著降低，但组间无显著差异。A 组副作用最小。
GA 单独或联合 TCA 的化学换肤确实能显著改善黄褐斑，但在同一时间联合使用这些换肤剂似乎没有任何附加或协同作用，反而可能增加副作用。
