Khoshdel Zahra, Gholijani Naser, Niknam Maryam, Rahmani Nasim, Hemmati-Dinarvand Mohsen, Naghibalhossaini Fakhraddin
Department of Biochemistry, Shiraz University of Medical Sciences, School of Medicine, Shiraz, Iran.
Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, School of Medicine, Shiraz, Iran.
Dermatol Pract Concept. 2022 Oct 1;12(4):e2022140. doi: 10.5826/dpc.1204a140. eCollection 2022 Nov.
Vitiligo is a chronic skin disease, which its etiopathogenesis is not fully understood. Numerous studies have suggested that oxidative stress may play a role in the pathophysiology of vitiligo. There are controversial reports as to the changes of serum trace elements, copper (Cu) and zinc (Zn) levels in vitiligo patients.
We evaluated the alterations in the level of serum Cu and Zn among a group of Iranian vitiligo patients.
The levels of serum Cu and Zn were compared between 117 vitiligo patients and 137 healthy controls using atomic absorption spectrophotometry.
The mean Cu and Zn levels in the cases (113.57 ± 59.43 and 95.01 ± 58.95 μg/dl, respectively) were significantly lower than those of the controls (138.90 ± 38.14 and 121.83 ± 33.80 μg/dl, respectively) (P = 0.00). We also observed significantly lower serum Cu and Zn concentrations in young (< 50 years) than the elderly (≥ 50 years) patients (P = 0.00). The mean Cu and Zn levels in the patients with generalized vitiligo (111.63±54.18 and 93.11±59.33 μg/dl, respectively) were significantly lower than patients with localized vitiligo (120.74 ±71.64 and 98.69±58.63 μg/dl, respectively) and those in the control (P = 0.00). The serum Cu/Zn ratio obtained in the young and male patients was higher than those in their matched controls (P = 0.01).
The current study has shown that the disturbance of serum Cu and Zn levels is associated with vitiligo, and may play an important role in the disease development of Iranian patients.
白癜风是一种慢性皮肤病，其发病机制尚未完全明确。大量研究表明，氧化应激可能在白癜风的病理生理过程中起作用。关于白癜风患者血清微量元素铜（Cu）和锌（Zn）水平的变化，存在有争议的报道。
我们评估了一组伊朗白癜风患者血清铜和锌水平的变化。
采用原子吸收分光光度法比较了117例白癜风患者和137例健康对照者的血清铜和锌水平。
病例组的平均铜和锌水平（分别为113.57±59.43和95.01±58.95μg/dl）显著低于对照组（分别为138.90±38.14和121.83±33.80μg/dl）（P = 0.00）。我们还观察到，年轻（<50岁）患者的血清铜和锌浓度显著低于老年（≥50岁）患者（P = 0.00）。泛发性白癜风患者的平均铜和锌水平（分别为111.63±54.18和93.11±59.33μg/dl）显著低于局限性白癜风患者（分别为120.74±71.64和98.69±58.63μg/dl）及对照组（P = 0.00）。年轻男性患者的血清铜/锌比值高于其匹配的对照组（P = 0.01）。
目前的研究表明，血清铜和锌水平的紊乱与白癜风有关，可能在伊朗患者的疾病发展中起重要作用。
