Bayram Mustafa, Doğan Bilal, Karabacak Ercan
Dr. Mustafa Bayram Clinic, Caddebostan Mh. Haldun Taner Sk. No: 10-12 Kadıköy, Istanbul, Turkey.
Department of Dermatology, Maltepe University Faculty of Medicine, Istanbul, Turkey.
Biol Trace Elem Res. 2025 Feb 20. doi: 10.1007/s12011-025-04536-x.
Vitiligo, characterized by melanocyte destruction and pigment loss, exhibits variable prevalence across different regions. Although its exact etiopathogenesis remains unclear, numerous hypotheses exist. This study aimed to assess the relationship between serum and intraerythrocyte zinc levels and vitiligo disease activity. We included 104 participants: 52 with vitiligo from Gata Haydarpaşa Training Hospital's Dermatology Clinic and 52 controls. Diagnosis was confirmed via physical examination and Wood's lamp. Blood samples were collected for zinc measurement. The mean age of the participants was 25.76 years and was similar in the control and vitiligo groups (p = 0.23). The mean disease duration was 5.2 years, 8 years in men and 3 years in women. Serum zinc levels, intraerythrocyte zinc levels, hemoglobin and hematocrit values did not differ between the control and vitiligo groups (p = 0.15; p = 0.27; p = 0.56; p = 0.61, respectively). Serum zinc levels, intraerythrocyte zinc levels, zinc concentration per mg of hemoglobin, hematocrit and Hb levels were similar in generalised and localised vitiligo groups (p = 0.49; p = 0.05; p = 0.15; p = 0.54; p = 0.25, respectively). Zinc levels in serum and intraerythrocytes did not significantly differ between vitiligo patients and controls. No correlation was found between disease type (generalized or localized) and zinc levels. Future research should explore zinc levels in affected skin or hair and compare with healthy individuals without skin conditions.
白癜风以黑素细胞破坏和色素脱失为特征，在不同地区的患病率各不相同。尽管其确切的发病机制尚不清楚，但存在众多假说。本研究旨在评估血清和红细胞内锌水平与白癜风疾病活动度之间的关系。我们纳入了104名参与者：52名来自加塔海达尔帕夏培训医院皮肤科门诊的白癜风患者和52名对照者。通过体格检查和伍德灯检查确诊。采集血样进行锌含量测定。参与者的平均年龄为25.76岁，对照组和白癜风组相似（p = 0.23）。平均病程为5.2年，男性为8年，女性为3年。对照组和白癜风组之间的血清锌水平、红细胞内锌水平、血红蛋白和血细胞比容值无差异（分别为p = 0.15；p = 0.27；p = 0.56；p = 0.61）。泛发型和局限型白癜风组的血清锌水平、红细胞内锌水平、每毫克血红蛋白的锌浓度、血细胞比容和血红蛋白水平相似（分别为p = 0.49；p = 0.05；p = 0.15；p = 0.54；p = 0.25）。白癜风患者和对照组之间血清和红细胞内的锌水平无显著差异。未发现疾病类型（泛发型或局限型）与锌水平之间存在相关性。未来的研究应探索受累皮肤或毛发中的锌水平，并与无皮肤疾病的健康个体进行比较。
