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在果蝇腹部复杂颜色模式形成中色素基因的调控。

The regulation of a pigmentation gene in the formation of complex color patterns in Drosophila abdomens.

机构信息

Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, United States of America.

Department of Biotechnical and Clinical Laboratory Science, Jacobs School of Medicine and Biomedical Science, University at Buffalo, The State University of New York (SUNY), New York, United States of America.

出版信息

PLoS One. 2022 Dec 19;17(12):e0279061. doi: 10.1371/journal.pone.0279061. eCollection 2022.

DOI:10.1371/journal.pone.0279061
PMID:36534652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9762589/
Abstract

Changes in the control of developmental gene expression patterns have been implicated in the evolution of animal morphology. However, the genetic mechanisms underlying complex morphological traits remain largely unknown. Here we investigated the molecular mechanisms that induce the pigmentation gene yellow in a complex color pattern on the abdomen of Drosophila guttifera. We show that at least five developmental genes may collectively activate one cis-regulatory module of yellow in distinct spot rows and a dark shade to assemble the complete abdominal pigment pattern of Drosophila guttifera. One of these genes, wingless, may play a conserved role in the early phase of spot pattern development in several species of the quinaria group. Our findings shed light on the evolution of complex animal color patterns through modular changes of gene expression patterns.

摘要

发育基因表达模式的变化与动物形态的进化有关。然而，复杂形态特征的遗传机制在很大程度上仍然未知。在这里，我们研究了导致 Drosophila guttifera 腹部复杂颜色模式中黄色色素基因表达的分子机制。我们发现，至少有五个发育基因可能共同激活黄色基因的一个顺式调控模块，在不同的斑点行和暗区中，组装出 Drosophila guttifera 腹部完整的色素模式。其中一个基因 wingless 在 quinaria 组的几个物种的斑点模式发育的早期阶段可能发挥保守作用。我们的研究结果通过基因表达模式的模块变化阐明了复杂动物颜色模式的进化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/850f4ee743d8/pone.0279061.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/e529a97668c3/pone.0279061.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/2a5dec8bb8de/pone.0279061.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/8712e01cb48c/pone.0279061.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/4eb8552dec4f/pone.0279061.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/8ef34c4fa960/pone.0279061.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/beefc4abbcbe/pone.0279061.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/38f8ad370c4c/pone.0279061.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/0b53db1ca24c/pone.0279061.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/98f3d58ae3c0/pone.0279061.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/850f4ee743d8/pone.0279061.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/e529a97668c3/pone.0279061.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/2a5dec8bb8de/pone.0279061.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/8712e01cb48c/pone.0279061.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/4eb8552dec4f/pone.0279061.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/8ef34c4fa960/pone.0279061.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/beefc4abbcbe/pone.0279061.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/38f8ad370c4c/pone.0279061.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/0b53db1ca24c/pone.0279061.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/98f3d58ae3c0/pone.0279061.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06c9/9762589/850f4ee743d8/pone.0279061.g010.jpg

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3
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5
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4
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5
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