Parkinson J S, Revello P T
Cell. 1978 Dec;15(4):1221-30. doi: 10.1016/0092-8674(78)90048-x.
The ability of E. coli to adapt to constant levels of attractant and repellent chemicals was studied by examining the patterns of flagellar movement in cells subjected to abrupt concentration changes. Wild-type bacteria exhibited transient responses to such stimuli, in support of previous findings. Nonchemotactic mutants of the cheX class responded to both attractants and repellents, but were unable to terminate these behavioral changes as long as the stimulating chemical was present. The sensory adaptation defect of cheX strains may be due to an inability to methylate several cytoplasmic membrane proteins that initiate changes in flagellar movement in response to chemoreceptor signals. Based on these results, possible mechanisms of stimulus transduction and sensory adaptation during chemotaxis are discussed.
通过检测经历突然浓度变化的细胞中鞭毛运动模式，研究了大肠杆菌适应恒定水平引诱剂和驱避剂化学物质的能力。野生型细菌对这类刺激表现出短暂反应，这支持了先前的研究结果。cheX类非趋化性突变体对引诱剂和驱避剂都有反应，但只要刺激化学物质存在，就无法终止这些行为变化。cheX菌株的感觉适应缺陷可能是由于无法甲基化几种细胞质膜蛋白，这些蛋白会根据化学感受器信号引发鞭毛运动的变化。基于这些结果，讨论了趋化作用过程中刺激转导和感觉适应的可能机制。
