Stähli Nadine Emanuela, Bigi Sandra, Grunt Sebastian, Lidzba Karen, Studer Martina
Division of Child Neurology (NES, SB, SG, KL, MS), Development & Rehabilitation, University Children's Hospital, Inselspital, Bern University Hospital, and University of Bern; and Department of Neurology (SB, MS), Inselspital, Bern University Hospital, and University of Bern, Switzerland.
Neurol Clin Pract. 2022 Dec;12(6):e210-e220. doi: 10.1212/CPJ.0000000000200081.
Accelerated long-term forgetting (ALF) describes the phenomenon of normal learning and memory performance after short delays, but greater forgetting after longer delays, which is not objectified in standardized memory tests. The topic is attracting increasing interest due to its clinical importance. Studies investigating pediatric ALF remain rare, and no systematic review exists.
Based on our systematic literature search, 12 studies were found. Although most studies investigated ALF in children with epilepsy (n = 9), there is also evidence of ALF in children after traumatic brain injury (n = 1) and 22q11.2 deletion syndrome (n = 1).
To date, only a dozen of studies have investigated pediatric ALF. There is evidence that ALF is not an epilepsy-specific disorder, replicating findings of studies with adult patients. Because ALF is missed using standardized assessments, we propose to add delayed time points of testing memory performance.
加速长期遗忘（ALF）描述的是在短时间延迟后记忆表现正常，但在长时间延迟后遗忘加剧的现象，这种现象在标准化记忆测试中未被客观化。由于其临床重要性，该主题正吸引着越来越多的关注。研究小儿ALF的研究仍然很少，且尚无系统综述。
基于我们的系统文献检索，共找到12项研究。尽管大多数研究调查了癫痫患儿的ALF（n = 9），但也有证据表明创伤性脑损伤患儿（n = 1）和22q11.2缺失综合征患儿（n = 1）存在ALF。
迄今为止，仅有十几项研究调查了小儿ALF。有证据表明ALF并非癫痫特异性疾病，这与针对成年患者的研究结果一致。由于使用标准化评估会遗漏ALF，我们建议增加记忆表现测试的延迟时间点。
