Fox J G, Goad M E, Garibaldi B A, Wiest L M
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139.
J Am Vet Med Assoc. 1987 Aug 1;191(3):343-4.
A 7-year-old adult male ferret had progressive hair loss that was bilaterally symmetric. Also clinically evident were severe dehydration, polydipsia, muffled heart sounds, weak femoral pulses, hepatomegaly, lethargy, weakness, temporal muscular atrophy, dyspnea, and weakness. The blood profile of the ferret indicated profound leukopenia, eosinopenia, and high phosphorus, BUN, creatinine, and potassium concentrations, as well as high aspartate transaminase activity; the albumin concentration was low. The serum cortisol concentration was 8.1 micrograms/dl. Necropsy and histologic findings confirmed a diagnosis of hyperadrenocorticism, complicated by dilatative cardiomyopathy, chronic active hepatitis, and renal disease.
一只7岁的成年雄性雪貂出现进行性双侧对称脱毛。临床上还明显存在严重脱水、多饮、心音低沉、股动脉搏动微弱、肝肿大、嗜睡、虚弱、颞肌萎缩、呼吸困难和肌无力。该雪貂的血液检查显示严重白细胞减少、嗜酸性粒细胞减少，以及高磷、高尿素氮、高肌酐和高钾浓度，同时天冬氨酸转氨酶活性也很高；白蛋白浓度较低。血清皮质醇浓度为8.1微克/分升。尸检和组织学检查结果确诊为肾上腺皮质功能亢进，并伴有扩张型心肌病、慢性活动性肝炎和肾病。
