Lipman N S, Marini R P, Murphy J C, Zhibo Z, Fox J G
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139.
J Am Vet Med Assoc. 1993 Dec 1;203(11):1552-5.
Severe generalized alopecia and marked vulvar enlargement were observed in a 5-year-old spayed ferret with high serum estradiol concentrations. A neoplastic left adrenal gland was removed. Staining of the neoplastic cells for estradiol was demonstrated by use of immunohistochemistry. Clinical findings in this ferret were typical of adrenal-associated endocrinopathy, a syndrome characterized by increased secretion of adrenocortical hormones by hyperplastic or neoplastic adrenal glands.
在一只5岁已绝育的雪貂身上观察到严重的全身性脱发和明显的外阴肿大，其血清雌二醇浓度很高。切除了左侧肾上腺肿瘤。通过免疫组织化学证实肿瘤细胞中存在雌二醇染色。这只雪貂的临床症状是肾上腺相关内分泌病的典型表现，该综合征的特征是增生性或肿瘤性肾上腺分泌的肾上腺皮质激素增加。
