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抑制胰腺α-淀粉酶活性的内生真菌-HT166S生物活性化合物的鉴定

Identification of Bioactive Compounds of the Endophytic Fungus -HT166S Inhibiting the Activity of Pancreatic α-Amylase.

作者信息

Ruzieva Dilorom, Gulyamova Tashkan, Nasmetova Saodat, Mukhammedov Iqbol, Rasulova Gulchehra

机构信息

Institute of Microbiology of the Academy of Sciences, Tashkent, Uzbekistan.

出版信息

Turk J Pharm Sci. 2022 Dec 21;19(6):630-635. doi: 10.4274/tjps.galenos.2021.05873.

DOI:10.4274/tjps.galenos.2021.05873
PMID:36544281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9780572/
Abstract

OBJECTIVES

(DM) is a worldwide increasing problem, associated with development of hyperlipidemia, coronary heart disease, hypertension, and other chronic diseases. Decreasing of glucose absorption by inhibition of α-amylase is one of the therapeutic approaches to retard diabetes type 2. Pancreatic α-amylase (PA) inhibition widely studied mechanism for determination of potential of natural compounds as antidiabetic agents. The aim of this work was identification of inhibitory secondary metabolites produced by , isolated from .

MATERIALS AND METHODS

The PA inhibitory activity of the secondary metabolites determined using iodometric method. Isolation of inhibitory compounds was carried out by column chromatography, thin layer chromatography and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis.

RESULTS

It was found that the inhibitory concentration of a compound, K-10 (Rf : 0.74), isolated from metanolic extract of A. was 4.82 mg/mL. LC-MS/MS analysis of K-10 showed polymethoxylated flavones (PMF).

CONCLUSION

The fungal endophyte A. -HT166S can be considered a source of PMF as potential agents for developing new PA inhibitors.

摘要

目的

糖尿病（DM）是一个在全球范围内日益严重的问题，与高脂血症、冠心病、高血压及其他慢性疾病的发生相关。通过抑制α-淀粉酶来减少葡萄糖吸收是延缓2型糖尿病的治疗方法之一。胰腺α-淀粉酶（PA）抑制是广泛研究的用于确定天然化合物作为抗糖尿病药物潜力的机制。这项工作的目的是鉴定从……分离出的……产生的抑制性次生代谢产物。

材料与方法

使用碘量法测定次生代谢产物的PA抑制活性。通过柱色谱、薄层色谱和液相色谱-串联质谱（LC-MS/MS）分析进行抑制性化合物的分离。

结果

发现从A.的甲醇提取物中分离出的一种化合物K-10（比移值：0.74）的抑制浓度为4.82mg/mL。K-10的LC-MS/MS分析显示为多甲氧基黄酮（PMF）。

结论

真菌内生菌A.-HT166S可被视为PMF的来源，作为开发新型PA抑制剂的潜在药物。