Wijesekara Tharuka, Xu Baojun
Department of Food Science and Technology, University of Peradeniya, Peradeniya 20400, Sri Lanka.
Food Science and Technology Program, Department of Life Sciences, BNU-HKBU United International College, Zhuhai 519087, China.
J Fungi (Basel). 2023 Oct 8;9(10):997. doi: 10.3390/jof9100997.
The study examines the intricate relationship between plants and the endophytic fungi inhabiting their tissues. These fungi harmoniously coexist with plants, forming a distinct symbiotic connection that has caught scientific attention due to its potential implications for plant health and growth. The diverse range of bioactive compounds produced by these fungi holds significant promise for human health. The review covers various aspects of this topic, starting by introducing endophytic microorganisms, explaining their colonization of different plant parts, and illuminating their potential roles in enhancing plant defense against diseases and promoting growth. The review emphasizes the widespread occurrence and diversity of these microorganisms among plant species while highlighting the complexities and significance of isolating and extracting bioactive compounds from them. It focuses on the health benefits of these bioactive compounds, including their capacity to exhibit antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. The review delves into the mechanisms behind these health-promoting effects, spotlighting how the compounds interact with cellular receptors, signaling pathways, and gene expression. In conclusion, the review provides a comprehensive overview of health-promoting bioactive compounds from plant endophytic fungi. It outlines their multifaceted impact, potential applications, and future research avenues in health and medicine.
该研究考察了植物与其组织内栖息的内生真菌之间的复杂关系。这些真菌与植物和谐共生，形成了一种独特的共生关系，因其对植物健康和生长的潜在影响而受到科学界的关注。这些真菌产生的多种生物活性化合物对人类健康具有重大前景。该综述涵盖了这一主题的各个方面，首先介绍内生微生物，解释它们在不同植物部位的定殖情况，并阐明它们在增强植物抗病能力和促进生长方面的潜在作用。该综述强调了这些微生物在植物物种中的广泛存在和多样性，同时突出了从它们中分离和提取生物活性化合物的复杂性和重要性。它着重介绍了这些生物活性化合物对健康的益处，包括它们表现出抗氧化、抗炎、抗菌和抗癌作用的能力。该综述深入探讨了这些促进健康作用背后的机制，重点介绍了这些化合物如何与细胞受体、信号通路和基因表达相互作用。总之，该综述全面概述了来自植物内生真菌的促进健康的生物活性化合物。它概述了它们的多方面影响、潜在应用以及在健康和医学领域的未来研究方向。
