环磷酸鸟苷-腺苷酸合成酶-干扰素基因刺激因子信号通路对器官炎性损伤和纤维化的影响
The effect of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway on organ inflammatory injury and fibrosis.
作者信息
Liu Yuliang, Li Yihui, Xue Li, Xiao Jie, Li Pengyong, Xue Wanlin, Li Chen, Guo Haipeng, Chen Yuguo
机构信息
Department of Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
The Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
出版信息
Front Pharmacol. 2022 Dec 5;13:1033982. doi: 10.3389/fphar.2022.1033982. eCollection 2022.
The cyclic GMP-AMP synthase-stimulator of interferon genes signal transduction pathway is critical in innate immunity, infection, and inflammation. In response to pathogenic microbial infections and other conditions, cyclic GMP-AMP synthase (cGAS) recognizes abnormal DNA and initiates a downstream type I interferon response. This paper reviews the pathogenic mechanisms of stimulator of interferon genes (STING) in different organs, including changes in fibrosis-related biomarkers, intending to systematically investigate the effect of the cyclic GMP-AMP synthase-stimulator of interferon genes signal transduction in inflammation and fibrosis processes. The effects of stimulator of interferon genes in related auto-inflammatory and neurodegenerative diseases are described in this article, in addition to the application of stimulator of interferon genes-related drugs in treating fibrosis.
环磷酸鸟苷-腺苷合成酶-干扰素基因刺激物信号转导通路在固有免疫、感染及炎症过程中至关重要。响应病原微生物感染及其他状况时，环磷酸鸟苷-腺苷合成酶（cGAS）识别异常DNA并启动下游I型干扰素反应。本文综述了干扰素基因刺激物（STING）在不同器官中的致病机制，包括纤维化相关生物标志物的变化，旨在系统研究环磷酸鸟苷-腺苷合成酶-干扰素基因刺激物信号转导在炎症和纤维化过程中的作用。本文还描述了干扰素基因刺激物在相关自身炎症性疾病和神经退行性疾病中的作用，以及干扰素基因刺激物相关药物在治疗纤维化中的应用。
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