Kamio Y
Department of Bacteriology, Shinshu University School of Medicine, Matsumoto, Japan.
J Bacteriol. 1987 Oct;169(10):4837-40. doi: 10.1128/jb.169.10.4837-4840.1987.
Putrescine and cadaverine are essential constituents of the peptidoglycan of Veillonella alcalescens, Veillonella parvula, and Selenomonas ruminantium and are necessary for the growth of these organisms (Y. Kamio and K. Nakamura, J. Bacteriol. 169:2881-2884, 1987, and Y. Kamio, H. Pösö, Y. Terawaki, and L. Paulin, J. Biol. Chem. 261:6585-6589, 1986). In this study, the structural specificity of the diamine requirement for normal cell growth of these bacteria was examined by using a series of diamines with a general structure of NH3+ X (CH2)n X NH3+. Diaminohexane (n = 6) which was incorporated into the peptidoglycan was as effective as putrescine (n = 4) and cadaverine (n = 5) for normal cell growth. However, diaminopropane (n = 3) and diaminoheptane (n = 7) were less effective for growth than diaminohexane, although they were incorporated into the peptidoglycan to the same extent.
腐胺和尸胺是产碱韦荣球菌、小韦荣球菌和反刍月形单胞菌肽聚糖的必需成分，也是这些微生物生长所必需的（Y. 神尾和K. 中村，《细菌学杂志》169:2881 - 2884，1987年；以及Y. 神尾、H. 波索、Y. 寺胁和L. 保林，《生物化学杂志》261:6585 - 6589，1986年）。在本研究中，通过使用一系列具有NH3+ X (CH2)n X NH3+ 一般结构的二胺，研究了这些细菌正常细胞生长对二胺需求的结构特异性。掺入肽聚糖中的己二胺（n = 6）对正常细胞生长的效果与腐胺（n = 4）和尸胺（n = 5）相同。然而，丙二胺（n = 3）和庚二胺（n = 7）对生长的效果不如己二胺，尽管它们掺入肽聚糖的程度相同。
