Competition between adsorbed fibrinogen and high-molecular-weight kininogen on solid surfaces incubated in human plasma (the Vroman effect): influence of solid surface wettability.

The influence of the surface energy on the competition between fibrinogen and high-molecular-weight kininogen has been studied with the use of a recently described wettability gradient method. One finding is that the decrease in the antifibrinogen binding on plasma incubated gradient surfaces was not associated with an increase in anti-HMWK binding at all parts of the gradient surfaces.