Wan Xiaoming, Zeng Weibin
Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Toxics. 2022 Nov 24;10(12):719. doi: 10.3390/toxics10120719.
The high concentration of trace elements in Chinese herbal medicine (CHM) is an important research topic for quality control. This study investigated the total concentration of trace elements in three herbs used as both medicine and supplementary food, including , , and Further, the effects of different preparation ways, such as decoct, granule, and oral liquid, on the bioaccessibility of trace elements in CHM were disclosed. Results indicated that the total concentrations of trace elements in these three herbs were lower than the medical standards, but the concentrations of As and Pb in CHMs were higher than the standards for supplementary food. Different preparations ways affect bioaccessibility. Powder and oral liquid show a high bioaccessibility possibly because of the grinding process and the repeated extraction with ethanol. Among the three different CHMs, Isatidis showed higher bioaccessibility of As, which may be related to the sulfur fumigation process of this CHM. The three investigated CHMs were found to be safe as medicine but presented risks as supplementary food. The apparent influence of preparation procedures on the bioaccessibility of trace elements indicated that it is necessary to appropriately regulate preparation processes for CHMs.
中药中微量元素的高含量是质量控制的一个重要研究课题。本研究调查了三种药食两用草药中的微量元素总含量，包括[草药名称1]、[草药名称2]和[草药名称3]。此外，还揭示了不同制备方式，如煎剂、颗粒剂和口服液，对中药中微量元素生物可及性的影响。结果表明，这三种草药中微量元素的总含量低于药用标准，但中药中砷和铅的含量高于辅食标准。不同的制备方式会影响生物可及性。粉剂和口服液显示出较高的生物可及性，这可能是由于研磨过程以及用乙醇反复提取。在这三种不同的中药中，板蓝根的砷生物可及性较高，这可能与其硫熏过程有关。所研究的三种中药作为药物是安全的，但作为辅食存在风险。制备程序对微量元素生物可及性的明显影响表明，有必要对中药的制备过程进行适当规范。
