Chen Yi-Gong, He Xing-Li-Shang, Huang Jia-Hui, Luo Rong, Ge Hong-Zhang, Wołowicz Anna, Wawrzkiewicz Monika, Gładysz-Płaska Agnieszka, Li Bo, Yu Qiao-Xian, Kołodyńska Dorota, Lv Gui-Yuan, Chen Su-Hong
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Chaowang Road 18, Hangzhou, Zhejiang Province, China.
Department of Inorganic Chemistry, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University, M. Curie Sklodowska Sq. 2, 20-031 Lublin, Poland.
Ecotoxicol Environ Saf. 2021 Aug;219:112336. doi: 10.1016/j.ecoenv.2021.112336. Epub 2021 May 25.
Heavy metals are widely distributed in the environment due to the natural processes and anthropogenic human activities. Their migration into no contaminated areas contributing towards pollution of the ecosystems e.g. soils, plants, water and air. It is recognized that heavy metals due to their toxicity, long persistence in nature can accumulate in the trophic chain and cause organism dysfunction. Although the popularity of herbal medicine is rapidly increasing all over the world heavy metal toxicity has a great impact and importance on herbal plants and consequently affects the quality of herbal raw materials, herbal extracts, the safety and marketability of drugs. Effective control of heavy metal content in herbal plants using in pharmaceutical and food industries has become indispensable. Therefore, this review describes various important factors such as ecological and environmental pollution, cultivation and harvest of herbal plants and manufacturing processes which effects on the quality of herbal plants and then on Chinese herbal medicines which influence human health. This review also proposes possible management strategies to recover environmental sustainability and medication safety. About 276 published studies (1988-2021) are reviewed in this paper.
由于自然过程和人类活动，重金属在环境中广泛分布。它们迁移到未受污染的地区，导致生态系统（如土壤、植物、水和空气）受到污染。人们认识到，重金属因其毒性和在自然界中的长期持久性，会在营养链中积累并导致生物体功能失调。尽管草药在全球的受欢迎程度迅速上升，但重金属毒性对草药植物有很大影响，进而影响草药原料、草药提取物的质量以及药品的安全性和市场适销性。有效控制制药和食品工业中使用的草药植物中的重金属含量已变得不可或缺。因此，本综述描述了各种重要因素，如生态和环境污染、草药植物的种植和收获以及制造过程，这些因素会影响草药植物的质量，进而影响对人类健康有影响的中药材。本综述还提出了恢复环境可持续性和药物安全性的可能管理策略。本文综述了约276项已发表的研究（1988 - 2021年）。
