Xu Zikai, Li Zhen, Dong Ying, Chen Yao, Li Ming, Song Baoying, Zhang Yang, Jiang Miaowen, Zhang Xuxiang
Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Biomedical Engineering Interdisciplinary Research Group, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Brain Circ. 2025 Apr 16;11(2):113-126. doi: 10.4103/bc.bc_72_24. eCollection 2025 Apr-Jun.
This bibliometric analysis investigates the role of antioxidant therapy in addressing neuropathic pain, emphasizing mechanistic insights and research trends from 2003 to 2024. Neuropathic pain, often unresponsive to standard treatments, is closely associated with oxidative stress as a key factor in its pathophysiology. This study utilizes the Web of Science Core Collection to analyze 699 articles related to "antioxidants" and "neuropathic pain." CiteSpace software was employed to examine publication trends, global collaborations, co-citation networks, and research hotspots. Results indicate a consistent rise in research activity, peaking in 2022, with China, India, and Italy as leading contributors. The University of Florence and Universidade Federal de Santa Maria emerged as prominent institutions, while influential authors included Pol Olga and Trevisan Gabriela. Key studies highlighted oxidative stress and neuropathic pain mechanisms, with neuroinflammation and specific molecular pathways gaining attention as emerging research foci. The findings underscore the growing interest in antioxidant therapies as potential interventions for neuropathic pain. Despite significant advances in understanding underlying mechanisms, there is a need for further exploration of novel antioxidants and their clinical applications. Enhanced international collaboration and the use of advanced molecular techniques are essential to drive future progress in this field.
这项文献计量分析研究了抗氧化疗法在治疗神经性疼痛中的作用，重点阐述了2003年至2024年的作用机制见解和研究趋势。神经性疼痛通常对标准治疗无反应，与氧化应激密切相关，氧化应激是其病理生理学的关键因素。本研究利用科学网核心合集分析了699篇与“抗氧化剂”和“神经性疼痛”相关的文章。使用CiteSpace软件来研究出版趋势、全球合作、共被引网络和研究热点。结果表明研究活动持续增加，在2022年达到峰值，中国、印度和意大利是主要贡献者。佛罗伦萨大学和圣玛丽亚联邦大学是突出的机构，而有影响力的作者包括波尔·奥尔加和特雷维桑·加布里埃拉。关键研究突出了氧化应激和神经性疼痛机制，神经炎症和特定分子途径作为新兴研究重点受到关注。研究结果强调了人们对抗氧化疗法作为神经性疼痛潜在干预措施的兴趣日益浓厚。尽管在理解潜在机制方面取得了重大进展，但仍需要进一步探索新型抗氧化剂及其临床应用。加强国际合作和使用先进的分子技术对于推动该领域未来的进展至关重要。
