Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, 98125 Messina, Italy.
Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy.
Biomolecules. 2022 Dec 19;12(12):1904. doi: 10.3390/biom12121904.
Atopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays a pivotal role in the pathogenesis and persistence of inflammatory lesions. Phototherapy represents one of the most used therapeutic options, with benefits in the clinical picture. Studies have demonstrated the immunomodulatory effect of phototherapy and its role in reducing molecule hallmarks of oxidative stress. In this review, we report the data present in literature dealing with the main signaling molecular pathways involved in oxidative stress after phototherapy to target atopic dermatitis-affected cells. Since oxidative stress plays a pivotal role in the pathogenesis of atopic dermatitis and its flare-up, new research lines could be opened to study new drugs that act on this mechanism, perhaps in concert with phototherapy.
特应性皮炎是一种慢性炎症性皮肤病，其中活性氧的过度产生在炎症病变的发病机制和持续存在中起着关键作用。光疗是最常用的治疗方法之一，对临床症状有好处。研究已经证明了光疗的免疫调节作用及其在减轻氧化应激分子特征方面的作用。在这篇综述中，我们报告了文献中关于光疗后参与氧化应激的主要信号分子途径的数据，以针对特应性皮炎受影响的细胞。由于氧化应激在特应性皮炎的发病机制及其发作中起着关键作用，因此可以开辟新的研究路线来研究作用于该机制的新药，也许可以与光疗联合使用。
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