Mo Qiuting, You Shiquan, Fu Hao, Wang Dongdong, Zhang Jiachan, Wang Changtao, Li Meng
Beijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.
Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing 100048, China.
Antioxidants (Basel). 2022 Nov 25;11(12):2333. doi: 10.3390/antiox11122333.
Oxidative stress is an important factor on both aging and disease. Among foods endowed with beneficial healthy properties, rice is a very useful material, not only because it has a good amino acid ratio and produces antioxidant peptides through microbial fermentation, but also for its inexpensive availability. In this study, rice was treated with , and the resulting mixture of small peptides with less than 11 amino acids (RFP) was extracted and purified from the fermentation broth. Subsequently, the antioxidant activity of RFP was assessed using the chemical model, cell biology, and animal model methods. RFP enhanced the expression of the antioxidant enzyme genes downstream of the KEAP1-NRF2/ARE pathway by promoting nuclear factor-erythroid 2-related factor 2 (NRF2) nuclear translocation while simultaneously removing lipid oxidation products and excess free radicals. These results suggest that RFP is a potential substance for resisting aging and disease caused by oxidative stress.
氧化应激是衰老和疾病的一个重要因素。在具有有益健康特性的食物中，大米是一种非常有用的物质，不仅因为它具有良好的氨基酸比例，能通过微生物发酵产生抗氧化肽，还因其价格低廉且易于获取。在本研究中，对大米进行了[具体处理方式未给出]处理，从发酵液中提取并纯化得到了由少于11个氨基酸组成的小肽混合物（大米发酵肽，RFP）。随后，采用化学模型、细胞生物学和动物模型方法评估了RFP的抗氧化活性。RFP通过促进核因子红细胞2相关因子2（NRF2）核转位，增强了KEAP1-NRF2/ARE通路下游抗氧化酶基因的表达，同时清除脂质氧化产物和过量自由基。这些结果表明，RFP是一种抵抗氧化应激引起的衰老和疾病的潜在物质。
