Beijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.
Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing 100048, China.
Nutrients. 2022 Jun 1;14(11):2324. doi: 10.3390/nu14112324.
UVA can cause oxidative stress and photoaging of cells. We established a UVA-induced oxidative stress model of human fibroblasts and focused on the antioxidant and anti-photoaging ability of fermented . Compared with the unfermented , fermented has better DPPH free radical and hydroxyl free radical scavenging ability, significantly reduces the content of reactive oxygen species (ROS), and improves the antioxidant level. Further studies have shown that the fermented can activate the Nrf2/Keap1 signaling pathway and up-regulate heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), catalase (CAT) and glutathione Peptide peroxidase (GSH-Px), and protect fibroblasts from oxidative stress caused by UVA. On the other hand, fermented significantly reduces the activity of metalloproteinases in the cell, thereby increasing the collagen and elastin in the cell, alleviating the photoaging caused by UVA. Finally, we concluded that the antioxidant capacity and anti-photoaging ability of fermented are better than that of unfermented .
UVA 可引起细胞氧化应激和光老化。我们建立了人成纤维细胞 UVA 诱导的氧化应激模型，重点研究了 的抗氧化和抗光老化能力。与未发酵的 相比，发酵的 具有更好的 DPPH 自由基和羟自由基清除能力，显著降低活性氧（ROS）含量，提高抗氧化水平。进一步的研究表明，发酵的 可以激活 Nrf2/Keap1 信号通路，上调血红素加氧酶-1（HO-1）、烟酰胺腺嘌呤二核苷酸（磷酸）醌氧化还原酶 1（NQO1）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px），从而保护成纤维细胞免受 UVA 引起的氧化应激。另一方面，发酵的 显著降低了细胞中金属蛋白酶的活性，从而增加了细胞中的胶原蛋白和弹性蛋白，缓解了 UVA 引起的光老化。最后，我们得出结论，发酵的 抗氧化能力和抗光老化能力优于未发酵的 。
