The First School of Clinical Medicine, Gannan Medical University, Ganzhou 341000, China.
Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
Cells. 2022 Dec 15;11(24):4071. doi: 10.3390/cells11244071.
Colorectal cancer (CRC) is a malignancy that seriously threatens human health, and metastasis from CRC is a major cause of death and poor prognosis for patients. Studying the potential mechanisms of small extracellular vesicles (sEVs) in tumor development may provide new options for early and effective diagnosis and treatment of CRC metastasis. In this review, we systematically describe how sEVs mediate epithelial mesenchymal transition (EMT), reconfigure the tumor microenvironment (TME), modulate the immune system, and alter vascular permeability and angiogenesis to promote CRC metastasis. We also discuss the current difficulties in studying sEVs and propose new ideas.
结直肠癌（CRC）是一种严重威胁人类健康的恶性肿瘤，CRC 的转移是患者死亡和预后不良的主要原因。研究小细胞外囊泡（sEVs）在肿瘤发展中的潜在机制可能为 CRC 转移的早期和有效诊断和治疗提供新的选择。在这篇综述中，我们系统地描述了 sEVs 如何介导上皮间质转化（EMT）、重新配置肿瘤微环境（TME）、调节免疫系统以及改变血管通透性和血管生成以促进 CRC 转移。我们还讨论了目前研究 sEVs 所面临的困难，并提出了新的思路。
