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小细胞外囊泡通过多种机制促进结直肠癌中前转移生态位的形成。

Small extracellular vesicles promote the formation of the pre-metastatic niche through multiple mechanisms in colorectal cancer.

作者信息

Wu Jiyang, Wang Xiaoxing, Li Zhengzhe, Yi Xiaomei, Hu Die, Wang Qi, Zhong Tianyu

机构信息

The First School of Clinical Medicine, Gannan Medical University, Ganzhou, China.

Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

出版信息

Cell Cycle. 2024 Jan;23(2):131-149. doi: 10.1080/15384101.2024.2311501. Epub 2024 Feb 11.

DOI:10.1080/15384101.2024.2311501
PMID:38341861
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11037293/
Abstract

Colorectal cancer (CRC) ranks among the most prevalent global malignancies, posing significant threats to human life and health due to its high recurrence and metastatic potential. Small extracellular vesicles (sEVs) released by CRC play a pivotal role in the formation of the pre-metastatic niche (PMN) through various mechanisms, preparing the groundwork for accelerated metastatic invasion. This review systematically describes how sEVs promote CRC metastasis by upregulating inflammatory factors, promoting immunosuppression, enhancing angiogenesis and vascular permeability, promoting lymphangiogenesis and lymphatic network remodeling, determining organophilicity, promoting stromal cell activation and remodeling and inducing the epithelial-to-mesenchymal transition (EMT). Furthermore, we explore potential mechanisms by which sEVs contribute to PMN formation in CRC and propose novel insights for CRC diagnosis, treatment, and prognosis.

摘要

结直肠癌（CRC）是全球最常见的恶性肿瘤之一，因其高复发和转移潜能对人类生命健康构成重大威胁。CRC释放的小细胞外囊泡（sEVs）通过多种机制在转移前生态位（PMN）的形成中起关键作用，为加速转移侵袭奠定基础。本综述系统地描述了sEVs如何通过上调炎症因子、促进免疫抑制、增强血管生成和血管通透性、促进淋巴管生成和淋巴网络重塑、决定器官嗜性、促进基质细胞活化和重塑以及诱导上皮-间质转化（EMT）来促进CRC转移。此外，我们探讨了sEVs促成CRC中PMN形成的潜在机制，并为CRC的诊断、治疗和预后提出了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10af/11037293/0db262353fa9/KCCY_A_2311501_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10af/11037293/0db262353fa9/KCCY_A_2311501_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10af/11037293/0db262353fa9/KCCY_A_2311501_F0001_OC.jpg

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Eur J Pharmacol. 2023 Jul 5;950:175722. doi: 10.1016/j.ejphar.2023.175722. Epub 2023 Apr 12.
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Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway.外泌体环状 RNA TUBGCP4 通过激活 Akt 信号通路促进血管内皮细胞突出和结直肠癌细胞转移。
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Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis.
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Cancer statistics, 2023.癌症统计数据，2023 年。
CA Cancer J Clin. 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763.
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A novel tRNA-derived fragment tRF-3022b modulates cell apoptosis and M2 macrophage polarization via binding to cytokines in colorectal cancer.一种新型 tRNA 衍生片段 tRF-3022b 通过与结直肠癌中的细胞因子结合调节细胞凋亡和 M2 巨噬细胞极化。
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