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细胞外囊泡在胃癌转移中的生物学作用。

The biological role of extracellular vesicles in gastric cancer metastasis.

作者信息

Lei Yun, Cai Shuang, Zhang Chun-Dong, Li Yong-Shuang

机构信息

Department of Surgical Oncology and 8th General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Department of Gastroenterology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

出版信息

Front Cell Dev Biol. 2024 Jan 25;12:1323348. doi: 10.3389/fcell.2024.1323348. eCollection 2024.

DOI:10.3389/fcell.2024.1323348
PMID:38333593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10850573/
Abstract

Gastric cancer (GC) is a tumor characterized by high incidence and mortality, with metastasis being the primary cause of poor prognosis. Extracellular vesicles (EVs) are an important intercellular communication medium. They contain bioactive substances such as proteins, nucleic acids, and lipids. EVs play a crucial biological role in the process of GC metastasis. Through mechanisms such as remodeling the tumor microenvironment (TME), immune suppression, promoting angiogenesis, and facilitating epithelial-mesenchymal transition (EMT) and mesothelial-mesenchymal transition (MMT), EVs promote invasion and metastasis in GC. Further exploration of the biological roles of EVs will contribute to our understanding of the mechanisms underlying GC metastasis and may provide novel targets and strategies for the diagnosis and treatment of GC. In this review, we summarize the mechanisms by which EVs influence GC metastasis from four aspects: remodeling the TME, modulating the immune system, influencing angiogenesis, and modulating the processes of EMT and MMT. Finally, we briefly summarized the organotropism of GC metastasis as well as the potential and limitations of EVs in GC.

摘要

胃癌（GC）是一种发病率和死亡率都很高的肿瘤，转移是其预后不良的主要原因。细胞外囊泡（EVs）是一种重要的细胞间通讯介质。它们含有蛋白质、核酸和脂质等生物活性物质。EVs在GC转移过程中发挥着关键的生物学作用。通过重塑肿瘤微环境（TME）、免疫抑制、促进血管生成以及促进上皮-间质转化（EMT）和间皮-间质转化（MMT）等机制，EVs促进了GC的侵袭和转移。进一步探索EVs的生物学作用将有助于我们理解GC转移的潜在机制，并可能为GC的诊断和治疗提供新的靶点和策略。在这篇综述中，我们从四个方面总结了EVs影响GC转移的机制：重塑TME、调节免疫系统、影响血管生成以及调节EMT和MMT过程。最后，我们简要总结了GC转移的器官趋向性以及EVs在GC中的潜力和局限性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/10850573/771f169b946c/fcell-12-1323348-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/10850573/215d71b5e554/fcell-12-1323348-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/10850573/91b5ab124860/fcell-12-1323348-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/10850573/06d7b8496af3/fcell-12-1323348-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/10850573/373857cc8d1a/fcell-12-1323348-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/10850573/771f169b946c/fcell-12-1323348-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/10850573/215d71b5e554/fcell-12-1323348-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/10850573/91b5ab124860/fcell-12-1323348-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/10850573/06d7b8496af3/fcell-12-1323348-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/10850573/373857cc8d1a/fcell-12-1323348-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3159/10850573/771f169b946c/fcell-12-1323348-g005.jpg

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本文引用的文献

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ACS Biomater Sci Eng. 2024 Jan 8;10(1):550-562. doi: 10.1021/acsbiomaterials.3c00394. Epub 2023 Dec 22.
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HMGB1 in exosomes derived from gastric cancer cells induces M2-like macrophage polarization by inhibiting the NF-κB signaling pathway.外泌体来源的 HMGB1 通过抑制 NF-κB 信号通路诱导胃癌细胞 M2 样巨噬细胞极化。
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Small Extracellular Vesicles Derived from Helicobacter Pylori-Infected Gastric Cancer Cells Induce Lymphangiogenesis and Lymphatic Remodeling via Transfer of miR-1246.
幽门螺杆菌感染的胃癌细胞衍生的小细胞外囊泡通过miR-1246的转移诱导淋巴管生成和淋巴管重塑。
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Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2.骨髓间充质干细胞来源的微囊泡通过转移血栓素-2促进幽门螺杆菌相关胃癌的进展。
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