Andersen Kristoffer Papsø, Gerke Oke
Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark.
Department of Nuclear Medicine, Odense University Hospital, 5000 Odense, Denmark.
Diagnostics (Basel). 2022 Nov 29;12(12):2993. doi: 10.3390/diagnostics12122993.
Method comparison studies comprised simple scatterplots of paired measurements, a 45-degree line as benchmark, and correlation coefficients up to the advent of Bland-Altman analysis in the 1980s. The Agatston score for coronary calcification is based on computed tomography of the heart, and it originated in 1990. A peculiarity of the Agatston score is the often-observed skewed distribution in screening populations. As the Agatston score has manifested itself in preventive cardiology, it is of interest to investigate how reproducibility of the Agatston score has been established. This review is based on literature findings indexed in MEDLINE/PubMed before 20 November 2021. Out of 503 identified articles, 49 papers were included in this review. Sample sizes were highly variable (10-9761), the main focus comprised intra- and interrater as well as intra- and interscanner variability assessments. Simple analysis tools such as scatterplots and correlation coefficients were successively supplemented by first difference, later Bland-Altman plots; however, only very few publications were capable of deriving Limits of Agreement that fit the observed data visually in a convincing way. Moreover, several attempts have been made in the recent past to improve the analysis and reporting of method comparison studies. These warrant increased attention in the future.
方法比较研究包括成对测量的简单散点图、作为基准的45度线以及直到20世纪80年代布兰德-奥特曼分析出现之前的相关系数。冠状动脉钙化的阿加斯顿评分基于心脏计算机断层扫描，它起源于1990年。阿加斯顿评分的一个特点是在筛查人群中经常观察到的偏态分布。由于阿加斯顿评分已在预防心脏病学中得到应用，研究其重复性是如何确立的很有意义。本综述基于2021年11月20日前MEDLINE/PubMed中索引的文献研究结果。在503篇已识别的文章中，49篇被纳入本综述。样本量差异很大（10 - 9761），主要重点包括评估评分者内和评分者间以及扫描仪内和扫描仪间的变异性。诸如散点图和相关系数等简单分析工具先后被一阶差分、后来的布兰德-奥特曼图所补充；然而，只有极少数出版物能够得出在视觉上令人信服地拟合观测数据的一致性界限。此外，最近已经进行了几次尝试来改进方法比较研究的分析和报告。这些在未来值得更多关注。
