两例非交通性脑积水胎儿连合下器官的早期退行性发育
Early Regressive Development of the Subcommissural Organ of Two Human Fetuses with Non-Communicating Hydrocephalus.
作者信息
Carmona-Calero Emilia M, González-Toledo Juan M, Hernández-Abad Luis G, Castañeyra-Perdomo Agustin, González-Marrero Ibrahim
机构信息
Departamento de Ciencias Médicas Básicas, Facultad de Ciencias de la Salud, Campus de Ofra, Universidad de La Laguna, 38320 Santa Cruz de Tenerife, Spain.
Instituto de Investigación y Ciencias Puerto del Rosario, 35600 Las Palmas de Gran Canaria, Spain.
出版信息
Children (Basel). 2022 Dec 14;9(12):1966. doi: 10.3390/children9121966.
Hydrocephalus is a central nervous system condition characterized by CSF buildup and ventricular hypertrophy. It is divided into two types: communicative and non-communicating hydrocephalus. Congenital hydrocephalus has been linked to several changes in the subcommissural organ (SCO). However, it is unclear whether these changes occur before or as a result of the hydrocephalic illness. This report presents three cases of human fetuses with hydrocephalus: one non-communicating case, two communicating cases, and two controls. Hematoxylin-Eosin (H&E) or cresyl violet and immunohistochemistry with anti-transthyretin were used to analyze SCO morphological and secretory changes. We conclude that in the cases presented here, there could be an early regression in the SCO of the communicating cases that is not present in the non-communicating case.
脑积水是一种中枢神经系统疾病，其特征是脑脊液积聚和脑室肥大。它分为两种类型：交通性脑积水和非交通性脑积水。先天性脑积水与连合下器官（SCO）的几种变化有关。然而，尚不清楚这些变化是在脑积水疾病之前发生还是其结果。本报告介绍了三例脑积水胎儿病例：一例非交通性病例、两例交通性病例以及两例对照。采用苏木精-伊红（H&E）或甲酚紫染色以及抗转甲状腺素蛋白免疫组织化学方法分析SCO的形态和分泌变化。我们得出结论，在此处呈现的病例中，交通性病例的SCO可能存在早期退化，而非交通性病例中不存在这种情况。
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