Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an 710054, China.
Genes (Basel). 2022 Dec 2;13(12):2270. doi: 10.3390/genes13122270.
Based on previous observational studies, the causal association between circulating adiponectin (CA) levels and ankylosing spondylitis (AS) risk remains unclear. Therefore, this study aims to investigate whether CA levels are related to the risk of AS. We carried out a bidirectional two-sample Mendelian randomization (MR) analysis to examine the causal correlation between CA levels and AS via published genome-wide association study (GWAS) datasets. Single-nucleotide polymorphisms (SNPs) related to CA levels were derived from a large GWAS that included 39,883 individuals of European descent. SNPs related to AS were obtained from the FinnGen consortium (2252 cases and 227,338 controls). The random-effects inverse variance weighted (IVW) method was the primary method utilized in our research. We also used four complementary approaches to improve the dependability of this study (MR-Egger regression, Weighted median, Weighted mode, and Simple mode). Random-effects IVW (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.79-1.27, = 0.984) and four complementary methods all indicated that genetically predicted CA levels were not causally related to the risk of AS. In reverse MR analysis, there is little evidence to support the genetic causality between the risk of AS and CA levels.
基于先前的观察性研究，循环脂联素（CA）水平与强直性脊柱炎（AS）风险之间的因果关系尚不清楚。因此，本研究旨在探讨 CA 水平是否与 AS 风险相关。我们通过已发表的全基因组关联研究（GWAS）数据集进行了双向两样本 Mendelian 随机化（MR）分析，以检查 CA 水平与 AS 之间的因果相关性。与 CA 水平相关的单核苷酸多态性（SNP）源自一项包含 39883 名欧洲血统个体的大型 GWAS。与 AS 相关的 SNP 来自 FinnGen 联盟（2252 例病例和 227338 例对照）。本研究主要采用随机效应逆方差加权（IVW）法。我们还使用了四种互补方法来提高本研究的可靠性（MR-Egger 回归、加权中位数、加权众数和简单模式）。随机效应 IVW（比值比 [OR]，1.00；95%置信区间 [CI]，0.79-1.27， = 0.984）和四种互补方法均表明，遗传预测的 CA 水平与 AS 风险之间没有因果关系。在反向 MR 分析中，几乎没有证据支持 AS 风险和 CA 水平之间的遗传因果关系。
