在沙特阿拉伯利雅得，人博卡病毒 A&B 的优势亚基因型为 ON-1 和 BA-IX。
ON-1 and BA-IX Are the Dominant Sub-Genotypes of Human Orthopneumovirus A&B in Riyadh, Saudi Arabia.
机构信息
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Biology Department, College of Science, Jouf University, Sakaka 41412, Saudi Arabia.
出版信息
Genes (Basel). 2022 Dec 5;13(12):2288. doi: 10.3390/genes13122288.
(HOPV) is the major viral pathogen responsible for lower respiratory tract infections (LRTIs) in infants and young children in Riyadh, Saudi Arabia. Yet, predominant HOPV subtypes circulating in this region and their molecular and epidemiological characteristics are not fully ascertained. A total of 300 clinical samples involving nasopharyngeal aspirates (NPAs), throat swabs, and sputum were collected during winter seasons of 2019/2020 and 2021/2022 for HOPV subtyping and genotyping. Of the 300 samples, HOPV was identified in 55 samples (18.3%) with a distinct predominance of type A viruses (81.8%) compared to type B viruses (18.2%). Importantly, the ON1 strain of HOPV-A and BA-IX strain of HOPV-B groups were found to be responsible for all the infections. Sequence analysis revealed a duplication region within 2nd HVR of G protein gene of ON1 and BA-IX strains. This nucleotide duplication exerted a profound effect on protein length and affinity towards cell receptors. Further, these modifications may aid the HOPV in immune evasion and recurrent infections. Data from this study showed that ON-1 genotype of HOPV-A and BA-IX genotype of HOPV-B were dominant in Riyadh, Saudi Arabia. Further, a duplication of sequence within 2nd HVR of G protein gene was found.
（HOPV）是导致沙特阿拉伯利雅得婴幼儿下呼吸道感染（LRTIs）的主要病毒病原体。然而，该地区流行的主要 HOPV 亚型及其分子和流行病学特征尚未完全确定。在 2019/2020 年和 2021/2022 年冬季，共采集了 300 份涉及鼻咽抽吸物（NPA）、咽喉拭子和痰的临床样本，用于 HOPV 亚型和基因型分析。在 300 个样本中，有 55 个样本（18.3%）检测到 HOPV，其中 A 型病毒（81.8%）明显多于 B 型病毒（18.2%）。重要的是，发现 HOPV-A 的 ON1 株和 HOPV-B 的 BA-IX 株是导致所有感染的原因。序列分析显示，ON1 和 BA-IX 株 G 蛋白基因第 2 高变区（HVR）内存在一个重复区域。这种核苷酸重复对蛋白质长度和与细胞受体的亲和力产生了深远影响。此外，这些修饰可能有助于 HOPV 逃避免疫和反复感染。本研究数据表明，HOPV-A 的 ON-1 基因型和 HOPV-B 的 BA-IX 基因型在沙特阿拉伯利雅得占优势。此外，还发现 G 蛋白基因第 2 高变区（HVR）内的序列重复。
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