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[血压正常的嗜铬细胞瘤与扩张型心肌病:一例报告]

[Pheochromocytoma with normal blood pressure and dilated cardiomyopathy: a case report].

作者信息

Imaoka C, Kanemoto N

机构信息

First Department of Internal Medicine, Tokai University School of Medicine, Kanagawa.

出版信息

J Cardiogr. 1986 Sep;16(3):735-45.

PMID:3655424
Abstract

A rare complication of normotensive pheochromocytoma with dilated cardiomyopathy is described. This 57-year-old man first experienced palpitation eight years ago when his blood pressure, electrocardiogram and chest radiograph were all within normal limits. Five years later he was admitted to another hospital because of palpitation and was diagnosed as having dilated cardiomyopathy on the basis of cardiac catheterization and cardiac muscle biopsy. In December, 1984, he was admitted to our hospital for treatment of congestive heart failure. On admission, his electrocardiogram revealed left atrial overloading, left axis deviation, left ventricular hypertrophy with intraventricular conduction disturbances and frequent premature ventricular contractions. Echocardiography revealed marked biventricular dilatation with severe hypokinesis of the interventricular septum and the posterior wall of the left ventricle, and a B-B' step of the anterior mitral leaflet. Fasting blood sugar was slightly elevated and a 75 g glucose tolerance test was abnormal. An abdominal echogram and abdominal CT revealed a 67 mm diameter mass immediately superior to the right kidney. Blood and urine catecholamine levels were significantly increased. He was diagnosed as having a pheochromocytoma. Interestingly, he had been normotensive during the eight years until his fatal outcome. He died of congestive heart failure. Needle necropsy findings of the adrenal revealed pheochromocytoma, and those of the cardiac muscle revealed enlarged muscle cells and mild fibrosis.

摘要

本文描述了一例伴有扩张型心肌病的血压正常的嗜铬细胞瘤罕见并发症。该57岁男性八年前首次出现心悸,当时其血压、心电图和胸部X光片均在正常范围内。五年后,他因心悸入住另一家医院,根据心导管检查和心肌活检被诊断为扩张型心肌病。1984年12月,他因充血性心力衰竭入住我院治疗。入院时,他的心电图显示左心房负荷过重、电轴左偏、左心室肥厚伴室内传导障碍及频发室性早搏。超声心动图显示双心室明显扩张,室间隔和左心室后壁严重运动减弱,二尖瓣前叶有B - B' 台阶。空腹血糖轻度升高,75克葡萄糖耐量试验异常。腹部超声和腹部CT显示右肾上方紧邻处有一个直径67毫米的肿块。血、尿儿茶酚胺水平显著升高。他被诊断为嗜铬细胞瘤。有趣的是,在直至其死亡的八年时间里他血压一直正常。他死于充血性心力衰竭。肾上腺针吸尸检结果显示为嗜铬细胞瘤,心肌针吸尸检结果显示肌细胞增大和轻度纤维化。

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[Pheochromocytoma with normal blood pressure and dilated cardiomyopathy: a case report].[血压正常的嗜铬细胞瘤与扩张型心肌病:一例报告]
J Cardiogr. 1986 Sep;16(3):735-45.
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[A case of adrenal pheochromocytoma with normotention and normal levels of urinary excretion of catecholamines].一例血压正常且儿茶酚胺尿排泄水平正常的肾上腺嗜铬细胞瘤病例
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Cardiac failure due to epinephrine-secreting pheochromocytoma: clinical, laboratory and pathological findings in a sudden death.嗜铬细胞瘤分泌肾上腺素导致的心力衰竭:一例猝死的临床、实验室及病理发现
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J Endocrinol Invest. 2006 Apr;29(4):363-6. doi: 10.1007/BF03344110.