Dermatology Department, Faculty of Pharmacy, University of Granada, 18001 Granada, Spain.
Dermatology Department, Virgen de las Nieves University Hospital, 18012 Granada, Spain.
Int J Environ Res Public Health. 2022 Dec 12;19(24):16678. doi: 10.3390/ijerph192416678.
Excipients are used as vehicles for topical treatments; however, there are not many studies that evaluate the impact of different excipients themselves. The aim of this research is to assess skin homeostasis changes in healthy individuals after using water/oil (W/O), oil/water (O/W), Beeler base, foam and Vaseline excipients. A within-person randomized trial was conducted that included healthy individuals without previous skin diseases. Skin barrier function parameters, including stratum corneum hydration (SCH), transepidermal water loss (TEWL), pH, temperature, erythema, melanin and elasticity (R0, R2, R5 and R7), were measured on the volar forearm before and after using each excipient. Sixty participants were included in the study, with a mean age of 32 years. After applying w/o excipient erythema decreased by 25 AU, ( < 0.001) and elasticity increased by 6%. After using the o/w excipient, erythema decreased by 39.36 AU ( < 0.001) and SCH increased by 6.85 AU ( = 0.009). When applying the Beeler excipient, erythema decreased by 41.23 AU ( < 0.001) and SCH increased by 15.92 AU ( < 0.001). Foam and Vaseline decreased TEWL and erythema. Excipients have a different impact on skin barrier function. Knowing the effect of excipients on the skin could help to develop new topical treatments and help specialists to choose the best excipient according to the pathology.
辅料被用作局部治疗的载体；然而，很少有研究评估不同辅料本身的影响。本研究旨在评估健康个体在使用水/油（W/O）、油/水（O/W）、Beeler 基底、泡沫和凡士林辅料后皮肤稳态的变化。进行了一项个体内随机试验，包括没有既往皮肤疾病的健康个体。在使用每种辅料之前和之后，测量皮肤屏障功能参数，包括角质层水分（SCH）、经表皮水分流失（TEWL）、pH 值、温度、红斑、黑色素和弹性（R0、R2、R5 和 R7）。该研究纳入了 60 名参与者，平均年龄为 32 岁。使用 w/o 辅料后，红斑减少了 25 AU（<0.001），弹性增加了 6%。使用 O/W 辅料后，红斑减少了 39.36 AU（<0.001），SCH 增加了 6.85 AU（=0.009）。使用 Beeler 辅料时，红斑减少了 41.23 AU（<0.001），SCH 增加了 15.92 AU（<0.001）。泡沫和凡士林降低了 TEWL 和红斑。辅料对皮肤屏障功能有不同的影响。了解辅料对皮肤的影响有助于开发新的局部治疗方法，并帮助专家根据病理选择最佳辅料。
