Effects of Extra Virgin Olive Oil and Petrolatum on Skin Barrier Function and Microtopography.

: Natural oils are widely promoted and used around the world as part of skincare. Among them, extra virgin olive oil (EVOO) stands out for its broad range of organic compositions and well-known moisturizing properties. This study aimed to evaluate the effects of topically applied EVOO compared to petrolatum on skin barrier function (SBF) and microtopography. : A within-person randomized clinical trial was conducted in healthy adult volunteers. EVOO and petrolatum were applied to defined areas on the volar forearm. Parameters related to the SBF, including stratum corneum hydration (SCH), transepidermal water loss (TEWL), temperature, and erythema, were assessed. The skin microtopography was evaluated through two approaches: (1) topographic parameters-surface roughness, desquamation, smoothness, and wrinkles; and (2) stratum corneum (SC) composition-corneocytes subtypes and the desquamation index (DI). The participants completed a tolerability questionnaire for each product. : A total of 54 participants (50% female; mean age: 28.57 ± 11.02 years) completed the study. Both EVOO and petrolatum significantly improved the SBF by increasing SCH and reducing erythema and skin temperature. Petrolatum additionally reduced TEWL. Regarding the skin microtopography, both products decreased the desquamation index and reduced the prevalence of mature corneocyte types (types 2-5). These effects were more pronounced with petrolatum. Notably, EVOO significantly increased the proportion of early-stage corneocytes (type 1). : Both EVOO and petrolatum effectively enhanced the SBF and improved the microtopographic features of the skin. While petrolatum exerted a stronger occlusive effect by reducing TEWL and desquamation, EVOO uniquely promoted epidermal renewal by increasing epidermal turnover.