Rubio-Santoyo Ana, Sanabria-de la Torre Raquel, Montero-Vílchez Trinidad, Girón-Prieto María Sierra, Gómez-Farto Almudena, Arias-Santiago Salvador
Medicine Department, School of Medicine, University of Granada, 18016 Granada, Spain.
Biosanitary Research Institute of Granada (ibs.GRANADA), 18014 Granada, Spain.
J Clin Med. 2025 Jul 2;14(13):4675. doi: 10.3390/jcm14134675.
: Natural oils are widely promoted and used around the world as part of skincare. Among them, extra virgin olive oil (EVOO) stands out for its broad range of organic compositions and well-known moisturizing properties. This study aimed to evaluate the effects of topically applied EVOO compared to petrolatum on skin barrier function (SBF) and microtopography. : A within-person randomized clinical trial was conducted in healthy adult volunteers. EVOO and petrolatum were applied to defined areas on the volar forearm. Parameters related to the SBF, including stratum corneum hydration (SCH), transepidermal water loss (TEWL), temperature, and erythema, were assessed. The skin microtopography was evaluated through two approaches: (1) topographic parameters-surface roughness, desquamation, smoothness, and wrinkles; and (2) stratum corneum (SC) composition-corneocytes subtypes and the desquamation index (DI). The participants completed a tolerability questionnaire for each product. : A total of 54 participants (50% female; mean age: 28.57 ± 11.02 years) completed the study. Both EVOO and petrolatum significantly improved the SBF by increasing SCH and reducing erythema and skin temperature. Petrolatum additionally reduced TEWL. Regarding the skin microtopography, both products decreased the desquamation index and reduced the prevalence of mature corneocyte types (types 2-5). These effects were more pronounced with petrolatum. Notably, EVOO significantly increased the proportion of early-stage corneocytes (type 1). : Both EVOO and petrolatum effectively enhanced the SBF and improved the microtopographic features of the skin. While petrolatum exerted a stronger occlusive effect by reducing TEWL and desquamation, EVOO uniquely promoted epidermal renewal by increasing epidermal turnover.
天然油脂作为护肤品的一部分在全球范围内得到广泛推广和使用。其中，特级初榨橄榄油（EVOO）因其广泛的有机成分和众所周知的保湿特性而脱颖而出。本研究旨在评估局部应用EVOO与凡士林相比对皮肤屏障功能（SBF）和微观形貌的影响。
在健康成年志愿者中进行了一项自身随机临床试验。将EVOO和凡士林涂抹于掌侧前臂的特定区域。评估与SBF相关的参数，包括角质层水合作用（SCH）、经表皮水分流失（TEWL）、温度和红斑。通过两种方法评估皮肤微观形貌：（1）地形参数——表面粗糙度、脱屑、光滑度和皱纹；（2）角质层（SC）组成——角质形成细胞亚型和脱屑指数（DI）。参与者针对每种产品完成一份耐受性问卷。
共有54名参与者（50%为女性；平均年龄：28.57±11.02岁）完成了该研究。EVOO和凡士林均通过增加SCH以及降低红斑和皮肤温度显著改善了SBF。凡士林还降低了TEWL。关于皮肤微观形貌，两种产品均降低了脱屑指数并减少了成熟角质形成细胞类型（2 - 5型）的比例。凡士林的这些效果更为明显。值得注意的是，EVOO显著增加了早期角质形成细胞（1型）的比例。
EVOO和凡士林均有效增强了SBF并改善了皮肤的微观形貌特征。凡士林通过降低TEWL和脱屑发挥了更强的封闭作用，而EVOO则通过增加表皮更新独特地促进了表皮修复。
