Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Andalucía Tech, E-29071 Málaga, Spain.
Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA-Plataforma BIONAND, E-29071 Málaga, Spain.
Int J Mol Sci. 2022 Dec 15;23(24):15972. doi: 10.3390/ijms232415972.
The dimethyl derivative of the immunomodulator itaconate has been previously shown to have anti-inflammatory, anti-oxidative, and immunomodulatory effects. In the present work, we evaluate the potential of dimethyl itaconate as an anti-angiogenic compound by using cultured endothelial cells and several in vitro assays that simulate key steps of the angiogenic process, including endothelial cell proliferation, migration, invasion, and tube formation. Our results show that dimethyl itaconate interferes with all the previously mentioned steps of the angiogenic process, suggesting that dimethyl itaconate behaves as an anti-angiogenic compound.
先前的研究表明，免疫调节剂衣康酸的二甲酯衍生物具有抗炎、抗氧化和免疫调节作用。在本研究中，我们通过培养的内皮细胞和几种体外实验评估了二甲酯作为抗血管生成化合物的潜力，这些实验模拟了血管生成过程中的关键步骤，包括内皮细胞增殖、迁移、侵袭和管腔形成。我们的研究结果表明，二甲酯干扰了血管生成过程中的所有上述步骤，这表明二甲酯是一种抗血管生成化合物。
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