NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, China.
J Exp Clin Cancer Res. 2020 Sep 30;39(1):204. doi: 10.1186/s13046-020-01709-5.
Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment-composed of tumor cells, surrounding cells, and secreted cytokines-provides a conducive environment for the growth and survival of tumors. Different components of the tumor microenvironment can regulate tumor development. In this review, we have discussed the regulatory role of the microenvironment in tumor angiogenesis. High expression of angiogenic factors and inflammatory cytokines in the tumor microenvironment, as well as hypoxia, are presumed to be the reasons for poor therapeutic efficacy of current anti-angiogenic drugs. A combination of anti-angiogenic drugs and antitumor inflammatory drugs or hypoxia inhibitors might improve the therapeutic outcome.
肿瘤血管生成对于肿瘤细胞的持续生存和发展是必要的，并且在其生长、侵袭和转移中发挥重要作用。肿瘤微环境由肿瘤细胞、周围细胞和分泌的细胞因子组成，为肿瘤的生长和存活提供了有利的环境。肿瘤微环境的不同成分可以调节肿瘤的发展。在这篇综述中，我们讨论了微环境在肿瘤血管生成中的调节作用。肿瘤微环境中血管生成因子和炎性细胞因子的高表达以及缺氧被认为是当前抗血管生成药物治疗效果不佳的原因。抗血管生成药物与抗肿瘤炎性药物或缺氧抑制剂的联合应用可能改善治疗效果。
