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地中海饮食中的橄榄油及其通过遗传和表观遗传学分析对心血管健康的生化和分子作用。

Olive Oil in the Mediterranean Diet and Its Biochemical and Molecular Effects on Cardiovascular Health through an Analysis of Genetics and Epigenetics.

机构信息

U.O.C. di Medicina Interna Con Stroke Care, Promozione della Salute, Materno-Infantile, Di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro" (ProMISE), Università degli Studi di Palermo (Italy), Piazza delle Cliniche n.2, 90127 Palermo, Italy.

出版信息

Int J Mol Sci. 2022 Dec 15;23(24):16002. doi: 10.3390/ijms232416002.

Abstract

Human nutrition is a relatively new science based on biochemistry and the effects of food constituents. Ancient medicine considered many foods as remedies for physical performance or the treatment of diseases and, since ancient times, especially Greek, Asian and pre-Christian cultures similarly thought that they had beneficial effects on health, while others believed some foods were capable of causing illness. Hippocrates described the food as a form of medicine and stated that a balanced diet could help individuals stay healthy. Understanding molecular nutrition, the interaction between nutrients and DNA, and obtaining specific biomarkers could help formulate a diet in which food is not only a food but also a drug. Therefore, this study aims to analyze the role of the Mediterranean diet and olive oil on cardiovascular risk and to identify their influence from the genetic and epigenetic point of view to understand their possible protective effects.

摘要

人类营养学是一门相对较新的科学,基于生物化学和食物成分的影响。古代医学认为许多食物是提高身体机能或治疗疾病的药物,自古以来,特别是希腊、亚洲和基督教前文化都同样认为它们对健康有有益的影响,而另一些人则认为有些食物可能会导致疾病。希波克拉底将食物描述为一种药物形式,并指出均衡的饮食可以帮助个人保持健康。了解分子营养学、营养素与 DNA 之间的相互作用以及获得特定的生物标志物可以帮助制定饮食计划,使食物不仅是食物,也是药物。因此,本研究旨在分析地中海饮食和橄榄油对心血管风险的作用,并从遗传和表观遗传的角度来确定它们的影响,以了解它们可能的保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89e8/9782563/f6482f2572fb/ijms-23-16002-g001.jpg

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