沙特贫血和非贫血高血压人群的血脂异常模式：一项横断面研究。
Patterns of Dyslipidemia in the Anemic and Nonanemic Hypertensive Saudi Population: A Cross-Sectional Study.
作者信息
Alfhili Mohammad A, Alsughayyir Jawaher, Basudan Ahmed M, Ghneim Hazem K, Alfaifi Mohammed, Alamri Hassan S, Awan Zuhier A, Algethami Mohammed R
机构信息
Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
出版信息
Int J Gen Med. 2022 Oct 21;15:7895-7906. doi: 10.2147/IJGM.S379597. eCollection 2022.
BACKGROUND
Risk factors of cardiovascular disease include dyslipidemia, hypertension (HTN), and anemia. Our objective is to assess the patterns of dyslipidemia in the anemic and non-anemic hypertensive Saudi population.
METHODS
A retrospective, cross-sectional study of the gender, blood pressure, lipid markers, and CBC parameters of 3111 subjects, which were retrieved from the database of Al-Borg Medical Laboratories over a six-year period (2014-2019), was carried out. Means were compared among study groups and the prevalence, association, and diagnostic accuracy of lipid markers for HTN were evaluated.
RESULTS
TG, LDL/HDL, and TG/HDL were significantly higher ( < 0.0001) in hypertensives. Anemia reduces TC and LDL ( < 0.0001) in both genders, and reduces all markers and increases HDL ( < 0.01) in male hypertensives. HTN was more prevalent in anemics with high TC than normal TC (38.23% vs 11.17%, < 0.001) and in non-anemics with high TG than normal TG (56.31% vs 21.22%, < 0.001). Furthermore, non-anemics with high TG/HDL had the highest risk for HTN (RR = 1.20, 95% CI = 1.1551-1.2473, < 0.0001). Elevated TC ( = 0.0142), TG ( < 0.0001), TC/HDL ( < 0.0001), LDL/HDL ( < 0.0001), and TG/HDL ( < 0.0001), and low HDL ( < 0.0001) were risk factors for HTN as shown by ORs. In anemics, high TC/HDL, LDL/HDL, and TG/HDL were not. Importantly, only TG and TG/HDL had a discriminating capacity for HTN.
CONCLUSION
The anemic state of hypertensive Saudi patients influences dyslipidemia which warrants further investigation.
背景
心血管疾病的危险因素包括血脂异常、高血压（HTN）和贫血。我们的目的是评估贫血和非贫血的沙特高血压人群中的血脂异常模式。
方法
对从Al-Borg医学实验室数据库中在六年期间（2014 - 2019年）检索到的3111名受试者的性别、血压、血脂标志物和全血细胞计数参数进行了一项回顾性横断面研究。比较了各研究组之间的均值，并评估了血脂标志物对高血压的患病率、关联性和诊断准确性。
结果
高血压患者的甘油三酯（TG）、低密度脂蛋白/高密度脂蛋白（LDL/HDL）和甘油三酯/高密度脂蛋白（TG/HDL）显著更高（<0.0001）。贫血会降低男女的总胆固醇（TC）和低密度脂蛋白（<0.0001），并降低男性高血压患者的所有标志物水平且提高高密度脂蛋白水平（<0.01）。高血压在高TC的贫血患者中比正常TC的贫血患者更常见（38.23%对11.17%，<0.001），在高TG的非贫血患者中比正常TG的非贫血患者更常见（56.31%对21.22%，<0.001）。此外，高TG/HDL的非贫血患者患高血压的风险最高（相对风险RR = 1.20，95%置信区间CI = 1.1551 - 1.2473，<0.0001）。如比值比（OR）所示，升高的TC（=0.0142）、TG（<0.0001）、TC/HDL（<0.0001）、LDL/HDL（<0.0001）和TG/HDL（<0.0001）以及降低的高密度脂蛋白（<0.0001）是高血压的危险因素。在贫血患者中，高TC/HDL、LDL/HDL和TG/HDL不是危险因素。重要的是，只有TG和TG/HDL对高血压具有鉴别能力。
结论
沙特高血压患者的贫血状态会影响血脂异常，这值得进一步研究。
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