干扰素β1，是肿瘤坏死因子α诱导的主要组织相容性复合体I类分子表达增加过程中的一个中间产物，也是组成型主要组织相容性复合体I类分子表达的自分泌调节因子。
Interferon beta 1, an intermediate in the tumor necrosis factor alpha-induced increased MHC class I expression and an autocrine regulator of the constitutive MHC class I expression.
作者信息
Leeuwenberg J F, van Damme J, Jeunhomme G M, Buurman W A
机构信息
Department of Surgery, University of Limburg, Maastricht, The Netherlands.
出版信息
J Exp Med. 1987 Oct 1;166(4):1180-5. doi: 10.1084/jem.166.4.1180.
Abstract
In conclusion, our observations indicate that the constitutive MHC class I expression is regulated by autocrine production of IFN-beta 1. TNF-alpha acts as an enhancer of the autocrine production of IFN-beta 1, and consequently as an enhancer of the MHC class I expression and viral protection.
摘要
总之，我们的观察结果表明，组成型MHC I类分子的表达受IFN-β1自分泌产生的调控。TNF-α作为IFN-β1自分泌产生的增强剂，因此作为MHC I类分子表达和病毒保护的增强剂。
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