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1
Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.鉴定人26-kD蛋白，即干扰素β2（IFN-β2），为白细胞介素1和肿瘤坏死因子诱导产生的一种B细胞杂交瘤/浆细胞瘤生长因子。
J Exp Med. 1987 Mar 1;165(3):914-9. doi: 10.1084/jem.165.3.914.
2
The role of interferon-beta 1 and the 26-kDa protein (interferon-beta 2) as mediators of the antiviral effect of interleukin 1 and tumor necrosis factor.干扰素-β1和26 kDa蛋白（干扰素-β2）作为白细胞介素1和肿瘤坏死因子抗病毒作用介质的作用。
J Immunol. 1987 Sep 15;139(6):1867-72.
3
Interleukin 1 and poly(rI).poly(rC) induce production of a hybridoma growth factor by human fibroblasts.白细胞介素1和聚肌苷酸-聚胞苷酸诱导人成纤维细胞产生杂交瘤生长因子。
Eur J Immunol. 1987 Jan;17(1):1-7. doi: 10.1002/eji.1830170102.
4
Induction and regulation of mRNA encoding 26-kDa protein in human cell lines treated with recombinant human tumor necrosis factor.重组人肿瘤坏死因子处理的人细胞系中编码26 kDa蛋白的mRNA的诱导与调控
Proc Natl Acad Sci U S A. 1987 Jul;84(13):4557-61. doi: 10.1073/pnas.84.13.4557.
5
Interleukin-HP1, a T cell-derived hybridoma growth factor that supports the in vitro growth of murine plasmacytomas.白细胞介素-HP1，一种由T细胞衍生的杂交瘤生长因子，可支持小鼠浆细胞瘤的体外生长。
J Exp Med. 1987 Mar 1;165(3):641-9. doi: 10.1084/jem.165.3.641.
6
High-affinity binding sites for human 26-kDa protein (interleukin 6, B cell stimulatory factor-2, human hybridoma plasmacytoma growth factor, interferon-beta 2), different from those of type I interferon (alpha, beta), on lymphoblastoid cells.人26 kDa蛋白（白细胞介素6、B细胞刺激因子-2、人杂交瘤浆细胞瘤生长因子、干扰素-β2）在淋巴母细胞样细胞上的高亲和力结合位点，与I型干扰素（α、β）的结合位点不同。
Eur J Immunol. 1987 Oct;17(10):1435-40. doi: 10.1002/eji.1830171008.
7
Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines.其他细胞因子对人成纤维细胞中干扰素-β2/B细胞分化因子BSF-2/肝细胞刺激因子基因的转录调控
J Immunol. 1988 Feb 1;140(3):974-7.
8
A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1.人二倍体成纤维细胞中的细胞因子网络：β-干扰素、肿瘤坏死因子、血小板衍生生长因子和白细胞介素-1的相互作用。
Mol Cell Biol. 1987 Jan;7(1):273-80. doi: 10.1128/mcb.7.1.273-280.1987.
9
B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-beta 2, HPGF).重组人26-kd蛋白（BSF-2、HuIFN-β2、HPGF）的B细胞生长调节及分化活性
EMBO J. 1987 May;6(5):1219-24. doi: 10.1002/j.1460-2075.1987.tb02357.x.
10
Induction of a 26-kDa-protein mRNA in human cells treated with an interleukin-1-related, leukocyte-derived factor.用一种白细胞介素-1相关的、白细胞衍生因子处理的人细胞中26-kDa蛋白mRNA的诱导。
Eur J Biochem. 1985 Oct 15;152(2):253-7. doi: 10.1111/j.1432-1033.1985.tb09191.x.

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1
Novel Biomarkers for Atherosclerotic Disease: Advances in Cardiovascular Risk Assessment.动脉粥样硬化疾病的新型生物标志物：心血管风险评估的进展
Life (Basel). 2023 Jul 27;13(8):1639. doi: 10.3390/life13081639.
2
Interleukin-6 and pulmonary hypertension: from physiopathology to therapy.白细胞介素-6 与肺动脉高压：从病理生理学到治疗。
Front Immunol. 2023 Jun 28;14:1181987. doi: 10.3389/fimmu.2023.1181987. eCollection 2023.
3
Diagnostic value of IL-6 for patients with asthma: a meta-analysis.白细胞介素-6对哮喘患者的诊断价值：一项荟萃分析。
Allergy Asthma Clin Immunol. 2023 May 12;19(1):39. doi: 10.1186/s13223-023-00794-3.
4
Interferons and other cytokines, genetics and beyond in COVID-19 and autoimmunity.新型冠状病毒肺炎与自身免疫性疾病中的干扰素和其他细胞因子、遗传学及其他方面
Cytokine Growth Factor Rev. 2021 Apr;58:134-140. doi: 10.1016/j.cytogfr.2021.01.004. Epub 2021 Jan 29.
5
Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11.白介素 6 家族细胞因子信号转导的结构解析及靶向治疗：聚焦白介素 11。
Front Immunol. 2020 Jul 16;11:1424. doi: 10.3389/fimmu.2020.01424. eCollection 2020.
6
Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6.电化学和光学生物传感器在白细胞介素 6 检测方面的最新进展。
Sensors (Basel). 2020 Jan 23;20(3):646. doi: 10.3390/s20030646.
7
Negative Correlation between Serum Cytokine Levels and Cognitive Abilities in Children with Autism Spectrum Disorder.自闭症谱系障碍儿童血清细胞因子水平与认知能力之间的负相关
J Intell. 2017 May 8;5(2):19. doi: 10.3390/jintelligence5020019.
8
Age Dependent Hypothalamic and Pituitary Responses to Novel Environment Stress or Lipopolysaccharide in Rats.大鼠下丘脑和垂体对新环境应激或脂多糖的年龄依赖性反应。
Front Behav Neurosci. 2018 Mar 19;12:55. doi: 10.3389/fnbeh.2018.00055. eCollection 2018.
9
Associations of Circulating Soluble Tumor Necrosis Factor-α Receptors 1 and 2 with Interleukin-6 Levels in an Aging Cohort of Injection Drug Users with or at High Risk for HIV Infection.在感染HIV或有感染HIV高风险的注射吸毒者老龄队列中，循环可溶性肿瘤坏死因子-α受体1和2与白细胞介素-6水平的关联。
AIDS Res Hum Retroviruses. 2015 Dec;31(12):1257-64. doi: 10.1089/AID.2015.0134. Epub 2015 Oct 13.
10
Revisiting the 1986 molecular cloning of interleukin 6.重温1986年白细胞介素6的分子克隆
Front Immunol. 2014 Sep 23;5:456. doi: 10.3389/fimmu.2014.00456. eCollection 2014.

本文引用的文献

1
Stimulation of fibroblast interferon production by a 22K protein from human leukocytes.人白细胞中一种22K蛋白对成纤维细胞干扰素产生的刺激作用。
J Gen Virol. 1985 Apr;66 ( Pt 4):693-700. doi: 10.1099/0022-1317-66-4-693.
2
Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1.同源干扰素诱导22K因子与内源性热原和白细胞介素-1有关。
Nature. 1985;314(6008):266-8. doi: 10.1038/314266a0.
3
Induction of a 26-kDa-protein mRNA in human cells treated with an interleukin-1-related, leukocyte-derived factor.用一种白细胞介素-1相关的、白细胞衍生因子处理的人细胞中26-kDa蛋白mRNA的诱导。
Eur J Biochem. 1985 Oct 15;152(2):253-7. doi: 10.1111/j.1432-1033.1985.tb09191.x.
4
Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts.人成纤维细胞中一种诱导型26 kDa蛋白编码序列的结构分析。
Eur J Biochem. 1986 Sep 15;159(3):625-32. doi: 10.1111/j.1432-1033.1986.tb09931.x.
5
A macrophage-derived factor required by plasmacytomas for survival and proliferation in vitro.浆细胞瘤在体外生存和增殖所需的一种巨噬细胞衍生因子。
Science. 1986 Aug 1;233(4763):566-9. doi: 10.1126/science.3726549.
6
Interleukin 1 and poly(rI).poly(rC) induce production of a hybridoma growth factor by human fibroblasts.白细胞介素1和聚肌苷酸-聚胞苷酸诱导人成纤维细胞产生杂交瘤生长因子。
Eur J Immunol. 1987 Jan;17(1):1-7. doi: 10.1002/eji.1830170102.
7
Interleukin-HP1, a T cell-derived hybridoma growth factor that supports the in vitro growth of murine plasmacytomas.白细胞介素-HP1，一种由T细胞衍生的杂交瘤生长因子，可支持小鼠浆细胞瘤的体外生长。
J Exp Med. 1987 Mar 1;165(3):641-9. doi: 10.1084/jem.165.3.641.
8
Regulation of human gamma-interferon and beta-interferon gene expression in PHA-activated lymphocytes.PHA激活的淋巴细胞中人类γ-干扰素和β-干扰素基因表达的调控
J Interferon Res. 1986 Apr;6(2):161-70. doi: 10.1089/jir.1986.6.161.
9
Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines.人β-2干扰素的cDNA及基因结构与表达，一种由生长刺激细胞因子诱导产生的独特类型。
EMBO J. 1986 Oct;5(10):2529-37. doi: 10.1002/j.1460-2075.1986.tb04531.x.
10
Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.一种对B细胞杂交瘤具有生长因子活性的T细胞衍生淋巴因子的纯化及氨基末端氨基酸序列分析
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9679-83. doi: 10.1073/pnas.83.24.9679.

鉴定人26-kD蛋白，即干扰素β2（IFN-β2），为白细胞介素1和肿瘤坏死因子诱导产生的一种B细胞杂交瘤/浆细胞瘤生长因子。

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

作者信息

Van Damme J, Opdenakker G, Simpson R J, Rubira M R, Cayphas S, Vink A, Billiau A, Van Snick J

出版信息

J Exp Med. 1987 Mar 1;165(3):914-9. doi: 10.1084/jem.165.3.914.

DOI:10.1084/jem.165.3.914
PMID:3493322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188297/
Abstract

A factor that promotes the growth of certain B cell hybridomas and of plasmacytomas is shown to be produced by normal human fibroblasts and by a line of human osteosarcoma cells (MG-63) after treatment with IL-1 or TNF. The hybridoma-plasmacytoma growth factor (HPGF) is identified with a 26 kD protein whose mRNA was previously shown to be induced in the same cells by the same inducers. First, poly(A)-rich RNA extracted from IL-1-treated cells could be enriched in HPGF-mRNA content by hybridization to 26 kD cDNA. Second, MG-63-derived HPGF purified to electrophoretic homogeneity was subjected to amino acid sequence analysis, whereby the NH2-terminal sequence was found to match the nucleotide sequence of a 26 kD cDNA clone.

摘要

已表明，一种促进某些B细胞杂交瘤和浆细胞瘤生长的因子是由正常人成纤维细胞以及一株人骨肉瘤细胞（MG-63）在经白细胞介素-1（IL-1）或肿瘤坏死因子（TNF）处理后产生的。杂交瘤-浆细胞瘤生长因子（HPGF）被鉴定为一种26 kD的蛋白质，其信使核糖核酸（mRNA）先前已表明可由相同的诱导剂在相同的细胞中诱导产生。首先，从经IL-1处理的细胞中提取的富含多聚腺苷酸（poly(A)）的RNA，通过与26 kD互补脱氧核糖核酸（cDNA）杂交，可使HPGF-mRNA含量得到富集。其次，将纯化至电泳纯的MG-63来源的HPGF进行氨基酸序列分析，结果发现其氨基末端序列与一个26 kD cDNA克隆的核苷酸序列相匹配。