Department of Emergency Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bandar Tun Razak, Kuala Lumpur 56000, Malaysia.
Department of Medical Microbiology and Immunology, Faculty of Medicine, Universiti Kebangsaan Malayia, Bandar Tun Razak, Kuala Lumpur 56000, Malaysia.
Medicina (Kaunas). 2022 Dec 5;58(12):1789. doi: 10.3390/medicina58121789.
: The objective of this study is to examine the effect of the BNT162b2 vaccine on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and pulse pressure (PP) before and 15 min after two doses that were given 21 days apart. : This active surveillance study of vaccine safety was conducted on 15 and 16 March (for the first dose) and 5 and 6 April (for the second dose) 2021 in an academic hospital. For both doses, SBP, DBP, MAP, and PP levels were measured before and 15 min after both doses were given to healthcare workers over the age of 18. The results of the study were based on measurements of the mean blood pressure (BP), the mean changes in BP, and the BP trends. : In total, 287 individuals received the vaccine. After the first dose, 25% ( = 72) of individuals had a decrease in DBP of at least 10 mmHg (mean DBP decrease: 15 mmHg, 95% CI: 14-17 mmHg), and after the second dose it was 12.5% (mean DBP decrease: 13 mmHg, 95% CI: 12-15 mmHg). After the first dose, 28.6% ( = 82) had a PP that was wider than 40 mmHg. After the first dose, 5.2% and 4.9% of the individuals experienced an increase or decrease in SBP, respectively, of more than 20 mmHg. After the second dose, the SBP of 11% ( = 32) decreased by at least 20 mmHg. : Improved understanding of vaccine effects on BP may help address vaccine hesitancy in healthcare workers.
: 本研究旨在探讨相隔 21 天接种两剂 BNT162b2 疫苗对收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）和脉压（PP）的影响，观察在两剂疫苗接种前及接种后 15 分钟时的血压变化。 : 本疫苗安全性主动监测研究于 2021 年 3 月 15 日和 16 日（第一剂）以及 4 月 5 日和 6 日（第二剂）在一家学术医院进行。对两剂疫苗均测量了 18 岁以上医护人员接种前和接种后 15 分钟的 SBP、DBP、MAP 和 PP 水平。研究结果基于平均血压（BP）测量值、BP 变化平均值和 BP 趋势。 : 总计 287 人接种了疫苗。第一剂后，25%（=72 人）的 DBP 下降至少 10mmHg（平均 DBP 下降：15mmHg，95%CI：14-17mmHg），第二剂后这一比例为 12.5%（平均 DBP 下降：13mmHg，95%CI：12-15mmHg）。第一剂后，28.6%（=82 人）的 PP 大于 40mmHg。第一剂后，5.2%和 4.9%的个体 SBP 分别升高或降低超过 20mmHg。第二剂后，11%（=32 人）的 SBP 至少下降 20mmHg。 : 更好地了解疫苗对 BP 的影响可能有助于解决医护人员对接种疫苗的犹豫。
