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在接受 mRNA-1273 疫苗接种者的血浆中检测到循环严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）疫苗抗原。

Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients.

机构信息

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.

出版信息

Clin Infect Dis. 2022 Mar 1;74(4):715-718. doi: 10.1093/cid/ciab465.

DOI:10.1093/cid/ciab465
PMID:34015087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8241425/
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. Eleven of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day 1 after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of immunoglobulin G (IgG) and immunoglobulin A (IgA).

摘要

对 13 名接受两剂 mRNA-1273 疫苗的参与者的纵向血浆样本进行了严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）蛋白检测。在首次疫苗注射后 1 天，13 名参与者中有 11 名就已经检测到 SARS-CoV-2 蛋白。可检测到的 SARS-CoV-2 蛋白的清除与免疫球蛋白 G（IgG）和免疫球蛋白 A（IgA）的产生相关。

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