Alcantara Juan M A, Osuna-Prieto Francisco J, Plaza-Florido Abel
PROFITH "PROmoting FITness and Health through Physical Activity" Research Group, Department of Physical and Sports Education, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, 18011 Granada, Spain.
Department of Health Sciences, Institute for Innovation & Sustainable Food Chain Development, Public University of Navarra, Campus Arrosadía, s/n., 31006 Pamplona, Spain.
Metabolites. 2022 Dec 4;12(12):1218. doi: 10.3390/metabo12121218.
In humans, the variation in resting metabolic rate (RMR) might be associated with health-related factors, as suggested by previous studies. This study explored whether the intra-assessment RMR variability (expressed as a coefficient of variation (CV; %)) is similar in men and women and if it is similarly associated with diverse health-related factors. The RMR of 107 young, and relatively healthy adults, was assessed using indirect calorimetry. Then, the CV for volumes of oxygen consumption (VO2) and carbon dioxide production (VCO2), respiratory exchange ratio (RER), and resting energy expenditure (REE) were computed as indicators of intra-assessment RMR variability. Body composition, cardiorespiratory fitness (peak VO2 uptake), circulating cardiometabolic risk factors, and heart rate and its variability (HR and HRV) were assessed. Men presented higher CVs for VO2, VCO2, and REE (all p ≤ 0.001) compared to women. Furthermore, in men, the intra-assessment RER variability was associated with vagal-related HRV parameters and with mean HR (standardized β = −0.36, −0.38, and 0.41, respectively; all p < 0.04). In contrast, no associations were observed in women. In conclusion, men exhibited higher variability (CVs for VO2, VCO2, and REE) compared to women. The CV for RER could be a potential marker of cardiometabolic risk in young men.
正如先前研究所表明的，在人类中，静息代谢率（RMR）的变化可能与健康相关因素有关。本研究探讨了评估内RMR变异性（以变异系数（CV；%）表示）在男性和女性中是否相似，以及它是否与多种健康相关因素有相似的关联。使用间接测热法评估了107名年轻且相对健康的成年人的RMR。然后，计算了耗氧量（VO2）、二氧化碳产生量（VCO2）、呼吸交换率（RER）和静息能量消耗（REE）的CV，作为评估内RMR变异性的指标。评估了身体成分、心肺适能（峰值VO2摄取量）、循环中的心脏代谢风险因素以及心率及其变异性（HR和HRV）。与女性相比，男性的VO2、VCO2和REE的CV更高（所有p≤0.001）。此外，在男性中，评估内RER变异性与迷走神经相关的HRV参数以及平均心率相关（标准化β分别为−0.36、−0.38和0.41；所有p<0.04）。相比之下，在女性中未观察到相关性。总之，与女性相比，男性表现出更高的变异性（VO2、VCO2和REE的CV）。RER的CV可能是年轻男性心脏代谢风险的一个潜在标志物。
