Bikov Andras, Dragonieri Silvano, Csoma Balazs, Mazzuca Carmen, Finamore Panaiotis, Rocchi Giulia, Putignani Lorenza, Guarino Michele, Scarlata Simone
Wythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Road, Manchester M23 9LT, UK.
Department of Respiratory Diseases, University of Bari Aldo Moro, 11 Piazza G. Cesare, 70124 Bari, Italy.
Microorganisms. 2022 Dec 13;10(12):2457. doi: 10.3390/microorganisms10122457.
The human body contains a very complex and dynamic ecosystem of bacteria. The bacteriome interacts with the host bi-directionally, and changes in either factor impact the entire system. It has long been known that chronic airway diseases are associated with disturbances in the lung bacteriome. However, less is known about the role of gut bacteriome in the most common respiratory diseases. Here, we aim to summarise the evidence concerning the role of the intestinal bacteriome in the pathogenesis and disease course of bronchial asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea. Furthermore, we discuss the consequences of an altered gut bacteriome on the most common comorbidities of these lung diseases. Lastly, we also reflect on the therapeutic potential of influencing the gut microbiome to improve disease outcomes.
人体包含一个非常复杂且动态的细菌生态系统。细菌群落与宿主进行双向相互作用，任何一个因素的变化都会影响整个系统。长期以来，人们都知道慢性气道疾病与肺部细菌群落的紊乱有关。然而，对于肠道细菌群落在最常见的呼吸系统疾病中的作用，我们了解得较少。在此，我们旨在总结有关肠道细菌群落在支气管哮喘、慢性阻塞性肺疾病和阻塞性睡眠呼吸暂停的发病机制及病程中所起作用的证据。此外，我们还将讨论肠道细菌群落改变对这些肺部疾病最常见合并症的影响。最后，我们也思考了通过影响肠道微生物群来改善疾病结局的治疗潜力。
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