Department of Pharmacy, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China.
Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Molecules. 2022 Dec 7;27(24):8640. doi: 10.3390/molecules27248640.
A disposable and portable electrochemical sensor was fabricated by integrating vertically-ordered silica mesoporous films (VMSF) and electrochemically reduced graphene (ErGO) on a screen-printed carbon electrode (SPCE). Such VMSF/ErGO/SPCEs could be prepared by a simple and controllable electrochemical method. Stable growth of VMSF on SPCE could be accomplished by the introduction of an adhesive ErGO nanolayer owing to its oxygen-containing groups and two-dimensional (2D) planar structure. An outer VMSF layer acting as a protective coating is able to prevent the leakage of the inner ErGO layer from the SPCE surface. Thanks to the electrostatic permselectivity and anti-fouling capacity of VMSF and to the good electroactive activity of ErGO, binary nanocomposites of VMSF and ErGO endow the SPCE with excellent analytical performance, which could be used to quantitatively detect doxorubicin (DOX) in biological samples (human serum and urine) with high sensitivity, good long-term stability, and low sample amounts.
一种一次性、便携式电化学传感器通过在丝网印刷碳电极（SPCE）上集成垂直有序的二氧化硅介孔膜（VMSF）和电化学还原氧化石墨烯（ErGO）制备而成。这种 VMSF/ErGO/SPCE 可以通过一种简单可控的电化学方法制备。由于含氧基团和二维（2D）平面结构，引入具有粘性的 ErGO 纳米层可以在 SPCE 上实现 VMSF 的稳定生长。外层 VMSF 层作为保护层，能够防止内层 ErGO 层从 SPCE 表面泄漏。得益于 VMSF 的静电选择性和抗污能力以及 ErGO 的良好电活性活性，VMSF 和 ErGO 的二元纳米复合材料赋予 SPCE 优异的分析性能，可用于高灵敏度、良好长期稳定性和低样品量地定量检测生物样品（人血清和尿液）中的阿霉素（DOX）。
