Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Molecules. 2022 Dec 13;27(24):8835. doi: 10.3390/molecules27248835.
Ingestion of water is a major route of human exposure to environmental contaminants. There have been numerous studies exploring the different compounds present in drinking water, with recent attention drawn to a new class of emerging contaminants: endocrine-disrupting compounds (EDCs). EDCs encompass a broad range of physio-chemically diverse compounds; from naturally occurring to manmade. Environmentally, EDCs are found as mixtures containing multiple classes at trace amounts. Human exposure to EDCs, even at low concentrations, is known to lead to adverse health effects. Therefore, the ability to evaluate EDC contamination with a high degree of sensitivity and accuracy is of the utmost importance. This review includes (i) discussion on the perceived and actual risks associated with EDC exposure (ii) regulatory actions that look to limit EDC contamination (iii) analytical methods, including sample preparation, instrumentation and bioassays that have been advanced and employed for multiclass EDC identification and quantitation.
摄入水是人类接触环境污染物的主要途径。已经有许多研究探索了饮用水中存在的不同化合物，最近引起关注的是一类新的新兴污染物：内分泌干扰化合物（EDCs）。EDCs 包含广泛的物理化学性质不同的化合物；既有天然存在的，也有人工合成的。在环境中，EDCs 作为混合物存在，以痕量包含多种类别。已知人类即使接触低浓度的 EDCs，也会导致不良的健康影响。因此，能够以高度的灵敏度和准确性评估 EDC 污染是至关重要的。本综述包括：（i）讨论与 EDC 暴露相关的感知和实际风险；（ii）旨在限制 EDC 污染的监管行动；（iii）分析方法，包括样品制备、仪器和生物测定，这些方法已经得到了发展和应用，用于多类 EDC 的识别和定量。
