Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 40015 Cluj-Napoca, Romania.
Biozoon GmbH, D-27572 Bremerhaven, Germany.
Int J Mol Sci. 2019 Sep 2;20(17):4291. doi: 10.3390/ijms20174291.
Lung cancer is the leading cause of cancer deaths worldwide. Therefore, for the prevention, diagnosis, prognosis and treatment of lung cancer, efficient preventive strategies and new therapeutic strategies are needed to face these challenges. Natural bioactive compounds and particular flavonoids compounds have been proven to have an important role in lung cancer prevention and of particular interest is the dose used for these studies, to underline the molecular effects and mechanisms at a physiological concentration. The purpose of this review was to summarize the current state of knowledge regarding relevant molecular mechanisms involved in the pharmacological effects, with a special focus on the anti-cancer role, by regulating the coding and non-coding genes. Furthermore, this review focused on the most commonly altered and most clinically relevant oncogenes and tumor suppressor genes and microRNAs in lung cancer. Particular attention was given to the biological effect in tandem with conventional therapy, emphasizing the role in the regulation of drug resistance related mechanisms.
肺癌是全球癌症死亡的主要原因。因此，为了预防、诊断、预后和治疗肺癌，需要有效的预防策略和新的治疗策略来应对这些挑战。天然生物活性化合物和特定的类黄酮化合物已被证明在肺癌预防中具有重要作用，特别值得关注的是用于这些研究的剂量，以强调在生理浓度下的分子作用和机制。本综述的目的是总结与药理作用相关的分子机制的最新知识状态，特别关注通过调节编码和非编码基因发挥抗癌作用。此外，本综述还重点关注了肺癌中最常见的改变和最具临床相关性的癌基因和肿瘤抑制基因以及 microRNAs。特别关注了与传统疗法相结合的生物学效应，强调了在调节耐药相关机制中的作用。
